Possible Interaction: Epinephrine and Tranylcypromine

“With noradrenaline, experiments have fulfilled this prediction,‘” but experiments with adrenaline have had mixed results ; tranylcypromine moderately potentiates some actions of adrenaline3 whereas phenelzine does not.’”

“It has now been shown, however, that serotonin is not responsible and that … level of noradrenaline in the brain.20 It is now recommended that tranylcypromine … adrenaline and ephedrine, which may be in " cold cures " and are available … (which release noradrenaline); and the iminodibenzyl antidepressants such as imipramine (" tofranil ").”

“In normal eyes, TCP inhibits the hypotensive phase after topical norepinephrine (nE); less after epinephrine (E); and not at all after isoproterenol.”

“Administration of the alpha 2-adrenoceptor antagonist idazoxan and the MAO inhibitor tranylcypromine elicited increases in hypothalamic extracellular levels of both adrenaline and noradrenaline by 208% and 229%, respectively.”

“ Tranylcypromine is a non-hydrazine monoamine oxidase inhibitor which impedes the oxidative deamination of adrenaline , nor-adrenaline and dopamine, Effects of overdosage include restlessness, hyperreflexia, sweating, tachycardia and either hyperor hypotension.”