Possible Interaction: Epinephrine and Tranexamic Acid

“… TXA … DEP can significantly reduce total blood loss (mean difference, 246.13; 95% CI, −369.95 to −122.32; P < 0.0001), hidden blood loss (mean … < 0.0001) and transfusion requirements (risk ratio, 0.50; 95% CI 0.28–0.90; P = 0.02) compared with the TXA alone.”

“Furthermore, TXA plus DEP was associated with less total blood loss and hidden blood loss by approximately 209.79 ml and 297.74 ml, respectively, than TXA alone.”

“The pooled results demonstrated that TXA plus DEP was associated with a lower transfusion rate than TXA alone (RR = 0.57, 95% CI 0.38–0.86, P = 0.006).”

“There was no significant difference in terms of intraoperative blood loss or the occurrence of deep venous … between the TXA plus DEP and TXA alone groups (P > 0.05).ConclusionsOur meta-analysis suggested that TXA … DEP significantly decreased the need for transfusion, total … hidden blood loss among THA patients.”

“ Epinephrine plus tranexamic acid reduced postoperative total blood loss and immune reaction.”

“Conclusions: The combined administration of low-dose epinephrine and tranexamic acid demonstrated an increased effect in reducing perioperative blood loss and the inflammatory response compared with tranexamic acid alone, with no apparent increased incidence of thromboembolic and other complications.”

“In this study, we evaluated whether the combined administration of low-dose epinephrine plus tranexamic acid reduced perioperative blood loss or inflammatory response further compared with tranexamic acid alone.”

“Results Comparison of epinephrine and tranexamic acid revealed significantly higher OARSI scores in the epinephrine group (epinephrine: 3.42±1.31, TA: 0.92±0.90; P<0.001).”

“The combined use of TXA and epinephrine was positively associated with a smaller postoperative hemoglobin drop.”