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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Epinephrine
drug:
Tolbutamide
Research Papers that Mention the Interaction
“Fifteen min after the tolbutamide injection, plasma epinephrine plus norepinephrine and norepinephrine levels fell to 87.5% and 67.4% of the initial values, respectively.”
Effect of tolbutamide on plasma catecholamine in insulin dependent diabetics.“The decrease in 86Rb efflux and the repolarization of the B cell membrane produced by adrenaline were attenuated by tolbutamide , which depolarizes by blocking ATP-sensitive K+ channels, and by arginine, which depolarizes because of its transport in a charged form.”
Adrenaline inhibition of insulin release: role of the repolarization of the B cell membrane“In the presence of epinephrine, tolbutamide enhanced cyclic accumulation but inhibited lipolysis.”
“ Tolbutamide blocked the lipolytic action of epinephrine , theophylline, and dibutyryl- 3′,5′-AMP on brown fat cells.”
“The inhibitors of secretion, adrenaline and somatostatin, counteracted the augmentation of [Ca2+]i which was induced by glucose, tolbutamide and forskolin.”
Effects of Adrenaline and Tolbutamide on Insulin Secretion in INS-1 Cells Under Voltage Control
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