Possible Interaction: Epinephrine and Tolazoline

“ Tolazoline enhanced the velocity of perfusion (P=2α<0.01), epinephrine caused a marked capillary constriction (P=2α<0.01), as well as —to a lesser extent —did dexamethasone (P=2α<0.05).”

“ Tolazoline inhibits the aggregation induced by epinephrine and norepinephrine more intensely than the beta-blockers.”

“The constrictor effect of epinephrine and nor-epinephrine was blocked or reversed by tolazoline , but not the effect of serotonin or hypercapnia.”

“In aspirin treated platelets, primary wave aggregatory responses to epinephrine were blocked in a competitive manner by tolazoline , ABI.”

“The inhibitory effects of NE and EPI on NTS neuronal activity were specifically blocked by the alpha-adrenergic receptor antagonist tolazoline , but not by the beta-adrenergic antagonist sotalol.”

“The stimulation of cyclic AMP formation by the combination of tolazoline and histamine was about the same as the stimulation by histamine alone (nonadditive), whereas the stimulatory effects by tolazoline and epinephrine were additive.”

“The diuretic effect of DS-30 as well as that of epinephrine was reversed by pretreatment with tolazoline , but not with propranolol.”

“Pretreatment with tolazoline reduced the inhibitory effect of nicotine, epinephrine and norepinephrine, whereas the following had no effect on response to nicotine and the catecholamines: phenoxybenzamine, dihydroergotamine, dl -propranolol and phenoxybenzamine in combination with dl -propranolol.”

“Similar depression could be shown from norepinephrine and epinephrine in the presence of tolazoline.”