Possible Interaction: Epinephrine and Tolazoline

“In aspirin treated platelets, primary wave aggregatory responses to epinephrine were blocked in a competitive manner by tolazoline , ABI.”

“ Tolazoline enhanced the velocity of perfusion (P=2α<0.01), epinephrine caused a marked capillary constriction (P=2α<0.01), as well as —to a lesser extent —did dexamethasone (P=2α<0.05).”

“ Tolazoline inhibits the aggregation induced by epinephrine and norepinephrine more intensely than the beta-blockers.”

“The constrictor effect of epinephrine and nor-epinephrine was blocked or reversed by tolazoline , but not the effect of serotonin or hypercapnia.”

“ Adrenaline (0.1–10 μg) was ineffective per se but when given after tolazoline it produced hyperthermia and after propranolol it produced hypothermia.”

“The respiratory effects of microinjection of adrenaline were blocked by previous injection of tolazoline.”

“The inhibitory effects of NE and EPI on NTS neuronal activity were specifically blocked by the alpha-adrenergic receptor antagonist tolazoline , but not by the beta-adrenergic antagonist sotalol.”

“The effects of adrenaline and noradrenaline are blocked by phentolamine and tolazoline ; the responses to acetylcholine, acetyl-beta-methylcholine and carbamyl-beta-methylcholine are antagonized by atropine over a specific concentration range.”

“The stimulation of cyclic AMP formation by the combination of tolazoline and histamine was about the same as the stimulation by histamine alone (nonadditive), whereas the stimulatory effects by tolazoline and epinephrine were additive.”

“1 In rat isolated vas deferens, the isotonic contractile responses to low doses of noradrenaline or adrenaline were antagonized, and those to high doses were potentiated, by yohimbine, piperoxan, phentolamine and tolazoline.”