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Last Updated: 2 years ago

Possible Interaction: Epinephrine and Timolol

supplement:

Epinephrine

drug:

Timolol

Research Papers that Mention the Interaction

When used in conjunction with timolol , other adrenergic amines, such as norepinephrine and epinephrine , produce an additional hypotensive response.
Archives of ophthalmology  •  1978  |  View Paper
The mixture of timolol and epinephrine reduced the pressure significantly more than did timolol or epinephrine alone, especially at 12 h after the last administration of the drops.
Graefe's Archive for Clinical and Experimental Ophthalmology  •  2004  |  View Paper
Timolol clearly augmented peak adrenalin concentration at maximal exercise capacity (1543 +/- 510 pg/ml, p less than 0.05).
Scandinavian journal of clinical and laboratory investigation  •  1987  |  View Paper
After crossover, epinephrine was significantly additive to timolol in reducing pressure only when administered three hours after timolol.
Previous studies have suggested that the effect on intraocular pressure resulting from the combined use of timolol and epinephrine might be different when they are administered hours rather than minutes apart.
There was an initial enhancement of pressure reduction when epinephrine was added to timolol in both sequences.
Archives of ophthalmology  •  1982  |  View Paper
An analysis of the interaction of timolol and adrenaline showed that the adrenaline effect diminished linearly with increasing timolol dose, which finally made the combination less effective than timolol alone.
The British journal of ophthalmology  •  1982  |  View Paper
Eyes treated with timolol had a 27.2% mean reduction of IOP, whereas fellow eyes treated with timolol and epinephrine had a 29% reduction.
On the 91st day, eyes treated with epinephrine had a 25.8% mean reduction of intraocular pressure from baseline, whereas their fellow eyes treated with epinephrine and timolol had a 33.9% reduction.
The ocular hypotensive effects of timolol and epinephrine were partially additive throughout the course of this study.
Archives of ophthalmology  •  1982  |  View Paper
The results showed a significant additive effect of adrenaline with the smaller dose of timolol , but with the larger dose of timolol the effect of adrenaline was antagonistic.
Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie. Albrecht von Graefe's archive for clinical and experimental ophthalmology  •  1981  |  View Paper
Patients who were treated first with epinephrine for 2 weeks and then supplemented with timolol had significantly lower intraocular pressures for at least 2 weeks than patients in the reverse treatment sequence.
The British journal of ophthalmology  •  1981  |  View Paper
Patients who were treated first with epinephrine for two weeks and then supplemented with timolol had significantly lower IOPs, for at least two weeks, than patients in the reverse treatment sequence.
Archives of ophthalmology  •  1981  |  View Paper
Pretreatment with timolol enhanced the mydriatic effect of epinephrine (from 35.8% to 71.9% pupillary dilation); pretreatment with epinephrine resulted in an apparent mydriatic effect for timolol.
Pretreatment with timolol significantly reduced the ocular hypotensive effect of epinephrine (from 15.3% to 4.6%); epinephrine pretreatment did not affect the pressure reduction of timolol.
Archives of ophthalmology  •  1980  |  View Paper
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