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Discover Supplement-Drug Interactions
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Last Updated: 2 months ago
supplement:
Epinephrine
drug:
Timolol
Research Papers that Mention the Interaction
“The mixture of timolol and epinephrine reduced the pressure significantly more than did timolol or epinephrine alone, especially at 12 h after the last administration of the drops.”
Adrenergic and adrenolytic effects on intraocular pressure“After crossover, epinephrine was significantly additive to timolol in reducing pressure only when administered three hours after timolol.”
“Previous studies have suggested that the effect on intraocular pressure resulting from the combined use of timolol and epinephrine might be different when they are administered hours rather than minutes apart.”
“There was an initial enhancement of pressure reduction when epinephrine was added to timolol in both sequences.”
“Eyes treated with timolol had a 27.2% mean reduction of IOP, whereas fellow eyes treated with timolol and epinephrine had a 29% reduction.”
“On the 91st day, eyes treated with epinephrine had a 25.8% mean reduction of intraocular pressure from baseline, whereas their fellow eyes treated with epinephrine and timolol had a 33.9% reduction.”
“The ocular hypotensive effects of timolol and epinephrine were partially additive throughout the course of this study.”
“Patients who were treated first with epinephrine for 2 weeks and then supplemented with timolol had significantly lower intraocular pressures for at least 2 weeks than patients in the reverse treatment sequence.”
“Patients who were treated first with epinephrine for two weeks and then supplemented with timolol had significantly lower IOPs, for at least two weeks, than patients in the reverse treatment sequence.”
“In the presence of timolol , aqueous formation was decreased further, approximately 7% more, in the epinephrine treated-eye as compared to the placebo-treated eye.”
“Pretreatment with timolol enhanced the mydriatic effect of epinephrine (from 35.8% to 71.9% pupillary dilation); pretreatment with epinephrine resulted in an apparent mydriatic effect for timolol.”
“Pretreatment with timolol significantly reduced the ocular hypotensive effect of epinephrine (from 15.3% to 4.6%); epinephrine pretreatment did not affect the pressure reduction of timolol.”
“Thus, with the addition of timolol to the wound to block the binding of locally generated epinephrine to the beta-adrenergic receptor, healing is improved.”
“ Epinephrine treatment decreased phosphorylation of the mitogen-activated protein kinases (MAPK) ERK1/2 and p38; these decreases were also reversed with timolol.”
“Pretreatment with timolol reduced, but did not completely eliminate, the cytotoxic effects of epinephrine.”
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