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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Epinephrine
drug:
Ticlopidine
Research Papers that Mention the Interaction
“Studies in animals and man have demonstrated that ticlopidine is a potent inhibitor of platelet aggregation induced by adenosine diphosphate (ADP), and variably inhibits aggregation due to collagen, adrenaline (epinephrine), arachidonic acid, thrombin, and platelet activating factor.”
Ticlopidine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in platelet-dependent disease states.“ Ticlopidine abolished the release of 14 C-5-HT induced by 5 μM epinephrine but it was not possible to evaluate this effect statistically.”
“ Ticlopidine significantly inhibits ADP, epinephrine and collagen induced platelet aggregation and release function as illustrated by reduction of serotonin release, and increase of the platelet disaggregation.”
“Our results demonstrate that epinephrine can overcome the inhibitory effect of ticlopidine on ADP-induced aggregation through a mechanism involving activation of Na+/H+ exchange and through an as yet unidentified mechanism sensitive to aspirin.”
Proaggregatory effect of epinephrine on rabbit platelets inhibited by ticlopidine.
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