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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Epinephrine and Ticlopidine



Research Papers that Mention the Interaction

Studies in animals and man have demonstrated that ticlopidine is a potent inhibitor of platelet aggregation induced by adenosine diphosphate (ADP), and variably inhibits aggregation due to collagen, adrenaline (epinephrine), arachidonic acid, thrombin, and platelet activating factor.
Drugs  •  1987  |  View Paper
Ticlopidine abolished the release of 14 C-5-HT induced by 5 μM epinephrine but it was not possible to evaluate this effect statistically.
Thrombosis research  •  1979  |  View Paper
Ticlopidine significantly inhibits ADP, epinephrine and collagen induced platelet aggregation and release function as illustrated by reduction of serotonin release, and increase of the platelet disaggregation.
Thrombosis research  •  1979  |  View Paper
Our results demonstrate that epinephrine can overcome the inhibitory effect of ticlopidine on ADP-induced aggregation through a mechanism involving activation of Na+/H+ exchange and through an as yet unidentified mechanism sensitive to aspirin.
Thrombosis research  •  1990  |  View Paper