Possible Interaction: Epinephrine and Thyroxine

“At T4 , the S, D and M pressures decreased significantly 8 ± 2, 18 ± 4 and 16 ± 2% in the epinephrine group.”

“Significant increases in the levels of adrenaline and noradrenaline were present at T3 and T4 (p < 0.001).”

“ Adrenaline tests identify fine disturbances in endocrine regulation and considerably raise the predictive value of such indicators as ACTH, insulin, TTH, T3, T4 and calcitonin.”

“In the presence of a fixed concentration of T4 , additions of 10(-8) and 10(-6) M epinephrine reduced the T4 effect on the enzyme.”

“ levothyroxine can potentiate the sharp increase of urinary epinephrine induced by insulin-induced hypoglycemia in untreated and treated athyrotic patients (5).”

“For example, thyroxine treatment increases the sensitivity of the isolated heart and uterus to adrenaline , noradrenaline, isoprenaline, aeetylcholine, histamine and 5-hydroxytryptamine, but markedly decreases the sensitivity of the isolated aorta to each of these drugs.”

“ T4 increased subepicardial ( EPI ) and subendocardial (ENDO) coronary blood flow.”

“A conclusion is made that adrenalin testing can suppress the activity of thyroid conversion of T4 into T3 and decrease the activity of TSH-stimulated deiodination.”

“The high correlation between adrenaline release and disappearance rates of T3 and T4 after trauma suggests that adrenaline may in some way be connected to the fall in serum T3 and T4 concentrations following major trauma.”

“Potentiation of adrenaline action by thyroxine can contribute to this process.”

“ Thyroxine produced a metabolic response after a latent period and potentiated the metabolic action of adrenaline.”