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Last Updated: 2 years ago

Possible Interaction: Epinephrine and Thiopental

supplement:

Epinephrine

Research Papers that Mention the Interaction

Low concentrations of ADP and epinephrine , which did not induce secondary aggregation in a control study, induced strong secondary aggregation in the presence of thiopental (> or = 100 microM).
Thiopental (> or = 100 microM) also increased the TXB2 formation induced by ADP and epinephrine.
Canadian journal of physiology and pharmacology  •  2001  |  View Paper
Plasma concentrations of adrenaline increased significantly compared with concentrations before induction, 1 min after intubation in both groups and at 2 min in the thiopentone group only.
Plasma concentrations of adrenaline were significantly greater in the thiopentone group than in the propofol group at both 1 and 2 min after intubation.
British journal of anaesthesia  •  1994  |  View Paper
It is supposed that thiopentone inhibits the depletion of adrenaline and reduces the effect of increased PRA.
Der Anaesthesist  •  1983  |  View Paper
These results suggest that thiopental sensitizes the heart to epinephrine in a dose-dependent manner.
Anesthesiology  •  1989  |  View Paper
Following thiopental, EPI doses for AVD, V Ect, V Bigem, and V Tach were reduced, as well as EPI dose differences for At Ect, AVD, V Ect, and V Bigem.
Thiopental reduces the EPI dose needed for AVD and ventricular, but not atrial, arrhythmias.
Anesthesiology  •  1982  |  View Paper
Challenge injections of epinephrine (5 microgram/kg of body weight) to ten sheep anesthetized with thiopental , and to the same number of animals after 45 minutes of anesthesia with thiopental/halothane, produced serious arrhythmias.
Canadian journal of comparative medicine : Revue canadienne de medecine comparee  •  1977  |  View Paper