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Discover Supplement-Drug Interactions
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Last Updated: 4 years ago
supplement:
Epinephrine
drug:
Thiopental
Research Papers that Mention the Interaction
“Low concentrations of ADP and epinephrine , which did not induce secondary aggregation in a control study, induced strong secondary aggregation in the presence of thiopental (> or = 100 microM).”
“ Thiopental (> or = 100 microM) also increased the TXB2 formation induced by ADP and epinephrine.”
Thiopental enhances human platelet aggregation by increasing arachidonic acid release.“Plasma concentrations of adrenaline increased significantly compared with concentrations before induction, 1 min after intubation in both groups and at 2 min in the thiopentone group only.”
“Plasma concentrations of adrenaline were significantly greater in the thiopentone group than in the propofol group at both 1 and 2 min after intubation.”
“It is supposed that thiopentone inhibits the depletion of adrenaline and reduces the effect of increased PRA.”
“These results suggest that thiopental sensitizes the heart to epinephrine in a dose-dependent manner.”
“Following thiopental, EPI doses for AVD, V Ect, V Bigem, and V Tach were reduced, as well as EPI dose differences for At Ect, AVD, V Ect, and V Bigem.”
“ Thiopental reduces the EPI dose needed for AVD and ventricular, but not atrial, arrhythmias.”
“Challenge injections of epinephrine (5 microgram/kg of body weight) to ten sheep anesthetized with thiopental , and to the same number of animals after 45 minutes of anesthesia with thiopental/halothane, produced serious arrhythmias.”
Prevention of thiopental and thiopental/halothane cardiac sensitization to epinephrine in the sheep.
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