Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
“When compared with placebo, theophylline significantly enhanced responses of plasma epinephrine , norepinephrine, and cortisol levels in both diabetic patients and control subjects.”
“The effects of epinephrine , histamine, and adenosine were inhibited by the addition of propranolol (a beta-adrenergic antagonist), cimetidine (histamine H2-antagonist), and theophylline (adenosinereceptor antagonist), respectively.”
Archives of Dermatological Research • 2004 | View Paper
“After EPI treatment for 72 h, IPR (10 microM for 3 min) in the presence of theophylline (4 mM) increased cAMP-levels by only 80% above baseline level (cAMP levels after maintained exposure to EPI), compared to 1080% above unstimulated level in control cells.”
“The effects on cell growth, differentiation and beta-adrenergic response were followed … culture period of 72 h. Short-term exposure (3 min) to EPI (1 nM-1 mM) … the presence of theophylline (4 mM) caused a dose-dependent increase of cAMP … with a maximum of 1500% above basal levels.”
Scandinavian journal of clinical and laboratory investigation • 1993 | View Paper
“In the presence of 0.3-1 microM epinephrine , however, theophylline dose-dependently increased the diastolic slope, the rate of spontaneous discharges and the force of contraction.”
“The increase in tissue level of cyclic AMP (+288 +/- 69%) induced by 0.3 mM theophylline in the presence of epinephrine was much greater than the increase (+73 +/- 19%) in the absence of epinephrine.”
European journal of clinical investigation • 1979 | View Paper
“ Epinephrine antagonizes the lipolysis induced by theophyline on the subscutaneous adipocytes, this action is increased by propranolol (a beta-adrenergic blocking agent).”