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Possible Interaction: Epinephrine and Tetrodotoxin

supplement:

Epinephrine

Research Papers that Mention the Interaction

Epinephrine (1.5 microM) and 4-aminopyridine (3 mM) increased the AP duration, while butanedione monoxime (20 mM) and tetrodotoxin (1 microM) shortened it.
Journal of cardiovascular electrophysiology  •  1994  |  View Paper
At some concentrations, the addition of sodium octyl sulfate increased the duration of block from TTX plus epinephrine, and epinephrine increased that from TTX plus CPEs.
Anesthesia and analgesia  •  2017  |  View Paper
In those studies, epinephrine combined with TTX prolonged blocks more than 10-fold, while reducing systemic toxicity.
Marine drugs  •  2011  |  View Paper
CONCLUSIONS Vasoconstriction in the perisciatic muscles by epinephrine may contribute to the prolongation of tetrodotoxin-induced sciatic nerve blocks and the reduction of systemic toxicity of tetrodotoxin.
Coinjection of epinephrine with tetrodotoxin prevented decreases in brain blood flow.
Coinjection of epinephrine with tetrodotoxin prevented tetrodotoxin-induced increases in perisciatic muscle blood flow over time and did not alter sciatic nerve blood flow.
It was found that sciatic nerve block duration could be greatly increased and systemic toxicity greatly decreased if epinephrine was injected with tetrodotoxin.
The mechanism that underlies epinephrine-mediated prolongation of tetrodotoxin nerve blocks is not known, but indirect evidence suggests that epinephrine may slow the clearance of tetrodotoxin from the site of injection.
Anesthesiology  •  2004  |  View Paper
CONCLUSION Combinations of epinephrine or bupivacaine with tetrodotoxin or with other high-potency toxins active on sodium channels should be examined for the potential to provide clinically useful, prolonged nerve blockade.
Epinephrine reduced measures of systemic distribution and increased the median lethal dose of tetrodotoxin from 40 to 53.6 nmole/kg, thus more than quadrupling the therapeutic index.
Epinephrine reduced the median effective concentration of tetrodotoxin for nociception from 37.6 to 11.5 microM and prolonged its duration, such that reversible blocks lasting > 13 h were achieved.
Anesthesiology  •  1998  |  View Paper
In a subpopulation of neurons (3/9) from P15-18 rats, EPI increased both the amplitude and frequency of miniature IPSCs (mIPSCs) recorded in the presence of tetrodotoxin (TTX) and under conditions where postsynaptic EPI effects were blocked, suggesting activation of adrenoceptors on presynaptic terminals in these cells.
Journal of neurophysiology  •  1998  |  View Paper