Possible Interaction: Epinephrine and Tetrahydrocannabinol (THC)

“ Adrenal epinephrine was decreased after a single THC administration and increased after 42 days.”

“Co-incubation of 0.1 microM epinephrine with 0.8 or 3.1 microgram/ml THC significantly stimulated lactate secretion when compared to epinephrine or THC alone, while only the high THC dose increased transferrin secretion.”

“Abstract The single … administration of Δ9-tetrahydrocannabinol (Δ9-THC ) at doses of 10 and 50 mg/kg produces a …-dependent increase in the contents of noradrenaline (NA) and adrenaline (AD) in the rat adrenal gland at the first phase (45–90 min), and thereafter, decline significantly (90–360 min).”

“Measurements of turnover of adrenal catecholamines made with the use … (α-M-pt), an inhibitor of tyrosine hydroxylase, show that Δ9-THC given acutely both at low and at high dose (a) decreases the rate … rate of depletion of NA and (c) increases the rate of depletion of AD.”

“Treatment with Δ9-THC (10 mg/kg/day) for 21 consecutive days significantly elevates only the AD content with increase in its turnover rate.”