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Last Updated: 2 months ago

Possible Interaction: Epinephrine and Tetracaine

supplement:

Epinephrine

Research Papers that Mention the Interaction

When tetracaine is used, the addition of epinephrine significantly prolongs the duration.
Der Anaesthesist  •  1994  |  View Paper
A significant difference was observed between the dermatomal level of sensory loss of touch and … loss of either pinprick or cold during onset, at 5 min in patients given tetracaine … epinephrine , at time of maximum spread in patients given tetracaine … the sitting position, and in all groups during regression.
Anesthesia and analgesia  •  1985  |  View Paper
Epinephrine hydrochloride in solution with each anesthetic increases the systemic toxicity of procaine and metycaine and decreases the toxicity of pontocaine and nupercaine significantly, but has no effect on the toxicity of the 5 other drugs tested.
The Journal of pharmacology and experimental therapeutics  •  1948  |  View Paper
In this study, we investigated whether the addition of epinephrine to tetracaine modulates these events.
The addition of epinephrine to tetracaine sustained large concentrations of glutamate.
These results suggest that the addition of epinephrine to tetracaine may increase its neurotoxicity, which may possibly be related to a sustained increase of glutamate concentrations in the CSF.
Anesthesia and analgesia  •  2001  |  View Paper
Epinephrine , but not levonordefrin, increased the toxicity and lethality of bupivacaine as well as the lethality of tetracaine.
Anesthesia progress  •  1989  |  View Paper