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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Epinephrine and Sulfinpyrazone

Research Papers that Mention the Interaction

A significant (p less than 0.02) reduction (50%) of the aggregation response of platelet-rich plasma to epinephrine was found in the group treated with sulfinpyrazone (n = 21) as compared with the placebo group (n = 20).
Also, adrenaline evoked a milder (p less than 0.01) potentiation of aggregation by thrombin of the washed platelet suspensions in the sulfinpyrazone versus the placebo group.
It is concluded that sulfinpyrazone (200 mg 4 times daily) normalizes the platelet response to epinephrine ; a relation with the drug-reported reduction of sudden death after myocardial infarction is suggested.
The American journal of cardiology  •  1982  |  View Paper
Abstract Sulphinpyrazone at low concentrations inhibits the in vitro aggregation of normal platelets induced by epinephrine , collagen and ristocetin.
Thrombosis research  •  1979  |  View Paper
Abstract The inhibitory action … release inducible by epinephrine , comprising several non-…, phenylbutazone and sulfinpyrazone —and other non-anti-inflammatory agents (NAA)—prostaglandin E 1 , adenosine, dipyridamole, methysergide and cyproheptadine—can be prevented, … to human platelet rich plasma of the essential fatty acid, 5,8,11,14 eicosatetraenoic (arachidonic) acid.
Biochemical pharmacology  •  1978  |  View Paper