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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Epinephrine
drug:
Sufentanil
Research Papers that Mention the Interaction
“ResultsThe addition of epinephrine significantly (P < 0.05) reduced the incidence of sedation and lightheadedness after epidural sufentanil at all data collection points, except two.”
Epinephrine reduces the sedative side effects of epidural sufentanil for labour analgesia“Reducing the sufentanil dose from 5 microg to 2.5 microg when combined with bupivacaine and epinephrine , decreases the incidence of pruritus without impeding the quality or duration of analgesia.”
“Verborgh found that the respiratory rate was significantly decreased from 15 min to 1 h after 75 pg of epidural sufentanil ; however, the addition of adrenaline significantly prolonged the duration of analgesia and decreased hypercapnia and caused a reduction in respiratory rate.”
“In contrast to Dr. Leicht’s results, and to our own data from an earlier study with epidural morphine (4), we were surprised to find that nonrespiratory side effects were less, and of shorter duration, when epinephrine 1:200,000 was added to sufentanil.”
“An early report suggested that the duration of epidural sufentanil postoperative analgesia may also be prolonged by the addition of epinephrine (5).”
“ Epinephrine had no effect on the terminal elimination half-life of morphine in the epidural space, but it decreased that of fentanyl and sufentanil.”
“For example, in the lumbar epidural space, epinephrine increased the mean residence time of morphine but decreased that of fentanyl and sufentanil.”
Epidural, Cerebrospinal Fluid, and Plasma Pharmacokinetics of Epidural Opioids (Part 2): Effect of Epinephrine“Conclusions: Our experimental data suggest that the combination of epinephrine and sufentanil might be the worst choice for the intensive care setting.”
“However, sufentanil at 0.3 nM enhanced the antiperistaltic activity of epinephrine in a supraadditive manner, whereas the effect on norepinephrine and dobutamine was less pronounced.”
“Adding adrenaline to epidural sufentanil also resulted in an increased analgesia but there was also a minor potentiation of all other behavioural parameters measured.”
“Administration of sufentanil in intact cats (group I), caused a significant increase in mean arterial blood pressure and adrenal vein plasma levels of norepinephrine, epinephrine , dopamine, and Met-enkephalin.”
“ Epinephrine decreased significantly in the hypothalamus at the high sufentanil dose.”
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