Possible Interaction: Epinephrine and Steroids

“ Epinephrine and norepinephrine appear to stimulate steroid secretion in Aves and to inhibit it in Pisces, while their action in Amphibia is controversial.”

“Conclusions: Steroid injection, smoking, increasing age, lesser number of days between steroid injection and surgery, and use of lidocaine with epinephrine are risk factors for postoperative trigger surgical infections.”

“Highdose steroids may suppress the hypothalamic pituitary and adrenal axis , even with short-term use [6].”

“The patient's steroid metabolism showed markedly increased levels of adrenal androgens , in particular of 17-hydroxyprogesterone amd 21-deoxycortisol.”

“Significant weaning of epinephrine infusions was possible, from a mean dose of 0.16 to 0.06 &mgr;g/(kg·min) (p = .008), within 24 hrs after the initiation of steroid administration, and this reduction was not offset by increases in other inotropic agents.”

“We postulate that the acute episode was induced by steroid administration that increased the production of epinephrine causing β2-stimulation, peripheral vasodilation, and congestive heart failure.”

“Intracellular epinephrine content was also enhanced by 11,17-oxygenated steroids (dexamethasone and cortisol), but not by the other 11-oxygenated compounds studied.”

“However, these results imply that continuous steroid use induces low AD secretion, and that steroid-dependent asthmatics have a decreased productive capacity against sudden asthmatic attack.”

“Its mechanism is hormonal, with anovulation or dysovulation, due to the continuous steroid feedback of adrenal origin on the hypothalamo-pituitary axis.”

“In most cases the Ki value was approximately 10(-7) M. At micromolar concentrations several steroids , notably estrone and estradiol, caused almost total inhibition of adrenal 3 beta-HSD activity.”