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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Epinephrine
drug:
Spironolactone
Research Papers that Mention the Interaction
“Thus, in primary aldosteronism adrenal changes induced by chronic spironolactone administration are probably a major cause for incorrect differentiation between adenoma and hyperplasia by adrenal scintigraphy.”
Adrenal scintigraphy in primary aldosteronism. Spironolactone as a cause of incorrect classification between adenoma and hyperplasia“Glucocorticoids, synthetic steroidal antiandrogens, aminoglutethimide, ketoconazole, and spironolactone also may be used to block adrenal androgens.”
“There was a significant positive correlation between the fall in blood pressure during spironolactone and following adrenal surgery.”
“There was a significant correlation between the fall in blood pressure during spironolactone treatment and after adrenal surgery though levels were generally slightly lower during the former therapy.”
“The hypotensive effect of spironolactone usually predicted the subsequent response to adrenal surgery.”
“ Adrenal renin was up-regulated in 5/6 nephrectomy and further stimulated with spironolactone , possibly serving as a stimulus for the adrenal aldosterone synthesis.”
Adrenal Aldosterone Biosynthesis Is Elevated in a Model of Chronic Renal Failure – Role of Local Adrenal Renin-Angiotensin System“Preincubation of adrenal cells with SL or 7 alpha-thio-SL caused time-dependent and concentration-dependent decreases in subsequent ACTH-stimulated cortisol production.”
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