Possible Interaction: Epinephrine and Sotalol

“Under the perfusion conditions …, the subsequent perfusion with sotalol only reversed the … induced by epinephrine or isoproterenol at 10 nM, but not at 10 μM. Furthermore, the degree of the DMR reversion … sotalol was found to be in an opposite relation with the duration of the initial agonist treatment.”

“Freezing induced by epinephrine was blocked by sotalol in Pnmt-KO mice.”

“The increase in cortisol production stimulated by adrenaline (10(-6) M) and noradrenaline (10(-6) M) was inhibited by sotalol (2 x 10(-5) M), but not by prazosin suggesting that catecholamines stimulate cortisol release through the beta-receptor subtype.”

“The metabolic effects of epinephrine were inhibited by the beta-adrenergic blocking agents, propranolol and sotalol , but not by the alpha-adrenergic blocking drug, phentolamine.”

“The increase in cyclic AMP content by either isoproterenol or epinephrine was inhibited by the β‐adrenoceptor antagonists sotalol and propranolol.”

“The beta-adrenergic blocker, sotalol , 5 mg/kg, iv, administered prior to adrenaline suppressed the increase in glycemia and the late decrease in serum potassium, but not the early hyperkalemia.”

“However, 0.5 mg/kg of Sotalol effectively blocked the “calorigenic” action of 0.5 μg/kg of epinephrine.”

“Since the metabolic effects of epinephrine have not been shown to be beta-adrenergic receptor-mediated changes, it is concluded that Sotalol has the unique property of blocking the metabolic action of epinephrine.”

“Summary Propranolol at doses of 5 and 30 mg/kg and sotalol in a dose of 100 mg/kg only partially inhibited the hyperglycemic response to epinephrine in the rat.”