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Last Updated: 2 months ago

Possible Interaction: Epinephrine and Sotalol

supplement:

Epinephrine

drug:

Sotalol

Research Papers that Mention the Interaction

Under the perfusion conditions …, the subsequent perfusion with sotalol only reversed the … induced by epinephrine or isoproterenol at 10 nM, but not at 10 μM. Furthermore, the degree of the DMR reversion … sotalol was found to be in an opposite relation with the duration of the initial agonist treatment.
Integrative biology : quantitative biosciences from nano to macro  •  2013  |  View Paper
Freezing induced by epinephrine was blocked by sotalol in Pnmt-KO mice.
Psychopharmacology  •  2016  |  View Paper
The metabolic effects of epinephrine were inhibited by the beta-adrenergic blocking agents, propranolol and sotalol , but not by the alpha-adrenergic blocking drug, phentolamine.
Biochemical pharmacology  •  1979  |  View Paper
The increase in cyclic AMP content by either isoproterenol or epinephrine was inhibited by the β-adrenoceptor antagonists sotalol and propranolol.
Journal of neurochemistry  •  1977  |  View Paper
However, 0.5 mg/kg of Sotalol effectively blocked the “calorigenic” action of 0.5 μg/kg of epinephrine.
Since the metabolic effects of epinephrine have not been shown to be beta-adrenergic receptor-mediated changes, it is concluded that Sotalol has the unique property of blocking the metabolic action of epinephrine.
Sotalol blocks this calorigenic action of epinephrine.
Japanese journal of pharmacology  •  1974  |  View Paper
SummaryPropranolol at doses of 5 and 30 mg/kg and sotalol in a dose of 100 mg/kg only partially inhibited the hyperglycemic response to epinephrine in the rat.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine  •  1974  |  View Paper