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Discover Supplement-Drug Interactions
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Last Updated: 2 months ago
supplement:
Epinephrine
drug:
Sotalol
Research Papers that Mention the Interaction
“Under the perfusion conditions …, the subsequent perfusion with sotalol only reversed the … induced by epinephrine or isoproterenol at 10 nM, but not at 10 μM. Furthermore, the degree of the DMR reversion … sotalol was found to be in an opposite relation with the duration of the initial agonist treatment.”
A label-free optical biosensor with microfluidics identifies an intracellular signalling wave mediated through the β(2)-adrenergic receptor.“Freezing induced by epinephrine was blocked by sotalol in Pnmt-KO mice.”
Epinephrine increases contextual learning through activation of peripheral β2-adrenoceptors“The metabolic effects of epinephrine were inhibited by the beta-adrenergic blocking agents, propranolol and sotalol , but not by the alpha-adrenergic blocking drug, phentolamine.”
“The increase in cyclic AMP content by either isoproterenol or epinephrine was inhibited by the β-adrenoceptor antagonists sotalol and propranolol.”
“However, 0.5 mg/kg of Sotalol effectively blocked the “calorigenic” action of 0.5 μg/kg of epinephrine.”
“Since the metabolic effects of epinephrine have not been shown to be beta-adrenergic receptor-mediated changes, it is concluded that Sotalol has the unique property of blocking the metabolic action of epinephrine.”
“ Sotalol blocks this calorigenic action of epinephrine.”
“SummaryPropranolol at doses of 5 and 30 mg/kg and sotalol in a dose of 100 mg/kg only partially inhibited the hyperglycemic response to epinephrine in the rat.”
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