Possible Interaction: Epinephrine and Somatostatin

“In conclusion, somatostatin counteracts the decrease of platelet aggregation response to ADP seen in saline studies, induces the appearance of platelet aggregates in diabetics and potentiates the aggregation response to epinephrine (in vitro) in both normals and diabetics.”

“In in vitro studies, somatostatin augmented the aggregation response to epinephrine in both normals and diabetics.”

“At both stages of fasting, epinephrine stimulated glucagon, secretion, and this was blocked by somatostatin.”

“ Somatostatin also inhibited this early glycogenolytic response when the epinephrine dose was increased fivefold.”

“Urinary excretion of norepinephrine, epinephrine , dopamine, PGE2, and PGF2alpha was suppressed under somatostatin.”

“If adrenaline acts via cyclic AMP as a second messenger it would suggest that adrenaline is safer when given with somatostatin than when given alone.”

“If adrenaline acts via cyclic AMP as a second messenger it would suggest that adrenaline is safer when given with somatostatin than when given alone.”

“The delayed afterdepolarizations or triggered action potentials induced by high-frequency electrical drive in the presence of epinephrine were also suppressed by somatostatin.”

“ Somatostatin potentiates the venoconstrictive activity of noradrenaline, adrenaline and dopamine, but not that of 5-hydroxytryptamine and tyramine.”

“Plasma NEFA levels were raised by somatostatin plus adrenaline (0·55 ± 0·04–1·82 ± 0·11 mmol l‐1 at 60 min).”

“Somatostatin plus adrenaline and somatostatin plus cortisol resulted in hyperglycaemia (at 240 min, somatostatin plus adrenaline 11·4 ± 0·4 mmol l‐1, P < 0·001; somatostatin plus cortisol 6·7 ± 0·3 mmol l‐1, P < 0·05; somatostatin alone 4·9 ± 0·4 mmol l‐1).”

“ Somatostatin suppressed insulin, glucagon and growth hormone secretion and both magnified and prolonged the hyperglycaemic effect of adrenaline (maximal at 105 min, 11.3 +/- 0.5 mmol/l, p less than 0.01 versus adrenaline alone).(ABSTRACT TRUNCATED AT 250 WORDS)”

“During epinephrine plus somatostatin , glucose production still increased transiently, but further suppression of glucose clearance caused more marked hyperglycemia.”