Possible Interaction: Epinephrine and Somatostatin

“In in vitro studies, somatostatin augmented the aggregation response to epinephrine in both normals and diabetics.”

“Urinary excretion of norepinephrine, epinephrine , dopamine, PGE2, and PGF2alpha was suppressed under somatostatin.”

“The delayed afterdepolarizations or triggered action potentials induced by high-frequency electrical drive in the presence of epinephrine were also suppressed by somatostatin.”

“During somatostatin infusion, epinephrine administration resulted in an enhanced and sustained elevation of total ketone body production from 4.4 +/- 0.8 to 15.1 +/- 1.2 mumol/kg/min (P less than 0.01 versus somatostatin alone).”

“During epinephrine plus somatostatin , glucose production still increased transiently, but further suppression of glucose clearance caused more marked hyperglycemia.”

“Normal subjects were infused 1) with epinephrine (50 ng/(kg.min)) for 180 min followed by epinephrine plus glucagon (3 …/(kg.min)) for 60 min after which the epinephrine infusion rate was increased (125 ng/(kg.min)) or 2) with epinephrine plus somatostatin (500 microgram/h) for 180 min.”

“Both somatostatin and propranolol completely prevented glucagon responses and diminished the glycemic response to epinephrine by 40 to 50 per cent.”

“At both stages of fasting, epinephrine stimulated glucagon, secretion, and this was blocked by somatostatin.”

“ Somatostatin also inhibited this early glycogenolytic response when the epinephrine dose was increased fivefold.”

“ Somatostatin reversed the [Ca2+]i elevation obtained by carbachol, epinephrine , tolbutamide, and glucose.”

“ Epinephrine (1 microM) and cholecystokinin octapeptide (10 nM) increased somatostatin release to 6.98 +/- 1.25 and 10.72 +/- 1.64%, respectively.”

“An IV infusion of 20 ng/kg/min of epinephrine increased plasma epinephrine levels to 918±103 pg/ml (P<0.001), and increased the baseline pancreatic output of insulin (P<0.05), glucagon (P<0.05) and somatostatin (P<0.05).”