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Possible Interaction: Epinephrine and Somatostatin

supplement:

Epinephrine

Research Papers that Mention the Interaction

In in vitro studies, somatostatin augmented the aggregation response to epinephrine in both normals and diabetics.
Diabete & metabolisme  •  1980  |  View Paper
Urinary excretion of norepinephrine, epinephrine , dopamine, PGE2, and PGF2alpha was suppressed under somatostatin.
Klinische Wochenschrift  •  2005  |  View Paper
The delayed afterdepolarizations or triggered action potentials induced by high-frequency electrical drive in the presence of epinephrine were also suppressed by somatostatin.
Journal of molecular and cellular cardiology  •  1987  |  View Paper
During somatostatin infusion, epinephrine administration resulted in an enhanced and sustained elevation of total ketone body production from 4.4 +/- 0.8 to 15.1 +/- 1.2 mumol/kg/min (P less than 0.01 versus somatostatin alone).
Diabetes  •  1984  |  View Paper
During epinephrine plus somatostatin , glucose production still increased transiently, but further suppression of glucose clearance caused more marked hyperglycemia.
Normal subjects were infused 1) with epinephrine (50 ng/(kg.min)) for 180 min followed by epinephrine plus glucagon (3 …/(kg.min)) for 60 min after which the epinephrine infusion rate was increased (125 ng/(kg.min)) or 2) with epinephrine plus somatostatin (500 microgram/h) for 180 min.
The American journal of physiology  •  1979  |  View Paper
Both somatostatin and propranolol completely prevented glucagon responses and diminished the glycemic response to epinephrine by 40 to 50 per cent.
Diabetes  •  1976  |  View Paper
At both stages of fasting, epinephrine stimulated glucagon, secretion, and this was blocked by somatostatin.
Somatostatin also inhibited this early glycogenolytic response when the epinephrine dose was increased fivefold.
The American journal of physiology  •  1977  |  View Paper
Somatostatin reversed the [Ca2+]i elevation obtained by carbachol, epinephrine , tolbutamide, and glucose.
Endocrinology  •  1999  |  View Paper
Epinephrine (1 microM) and cholecystokinin octapeptide (10 nM) increased somatostatin release to 6.98 +/- 1.25 and 10.72 +/- 1.64%, respectively.
The American journal of physiology  •  1988  |  View Paper
An IV infusion of 20 ng/kg/min of epinephrine increased plasma epinephrine levels to 918±103 pg/ml (P<0.001), and increased the baseline pancreatic output of insulin (P<0.05), glucagon (P<0.05) and somatostatin (P<0.05).
International journal of pancreatology : official journal of the International Association of Pancreatology  •  1988  |  View Paper
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