Possible Interaction: Epinephrine and Sodium Chloride

“Conversely, the affinity of adrenaline and noradrenaline was decreased in the presence of NaCl , and there was no change in the affinity of the imidazoline agonists.”

“ NaCl significantly decreased the affinity of the catecholamines adrenaline and noradrenaline, whereas the affinity of UK-14,304 and oxymatazoline was much less affected.”

“In the presence of 100 microM GTP, Gpp(NH)p or 150 mM NaCl , the competition curve for epinephrine was shifted to the right, whereas that for yohimbine was unaffected.”

“ Epinephrine was oxidized rapidly in sodium chloride prepared with tap water (1.20 +/- 0.12 nmoles/min) or in deionized water (0.40 +/- 0.80 nmoles/min), but this oxidation was prevented by the addition of Desferal, a potent metal chelating agent.”

“On … of NaCl in the assay … ability of epinephrine in competing with [3H]yohimbine for the receptor sites in the kidney and in the brain, and this effect of … same in a given tissue between S and R rats, whether they were fed a low or high salt diet.”

“On the other hand, when present together, epinephrine , GTP (10(-5) M) and NaCl (200 mM) acted synergistically to cause a 27% inhibition of basal activity.”

“In MDCK cell cultures we found that each state of increased NaCl transport during stimulation of AC by either epinephrine (10(-6) M), isoprenaline (10(-5) M), or forskolin (10(-5) M) was accompanied by a twofold increase in PG release.”

“Moreover, 150 mM NaCl was found to modulate the affinity of epinephrine for the [3H]prazosin-bound soluble complex, as previously described for membrane preparations.”

“Guanyl nucleotides and NaCl were additive in decreasing the affinity of epinephrine at the alpha 1-receptor but were synergistic at the alpha 2-receptor.”

“ NaCl decreased the affinity of epinephrine at both alpha-receptor subtypes; this effect was more Na+-selective at alpha 2- than at alpha 1-receptors.”

“Increasing osmolarity with sodium chloride diminished the lipolytic response to epinephrine.”

“ Epinephrine stimulates active NaCl absorption and decreases short-circuit current (SCC) in vitro, the latter effect due to inhibition of HCO3 secretion.”