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Discover Supplement-Drug Interactions
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Last Updated: 2 months ago
supplement:
Epinephrine
supplement:
Sodium Bicarbonate
Research Papers that Mention the Interaction
“ Epinephrine concentration declined approximately 25% per week in anesthetic solution containing 100 meq/L sodium bicarbonate.”
“The pain of infiltrating lidocaine with epinephrine into skin is reduced by the addition of sodium bicarbonate.”
Neutralized lidocaine with epinephrine for local anesthesia.“Conversely, we must keep in mind that medical resuscitation using a beta-agonist drug epinephrine ) and sodium bicarbonate can induce transfer hypokalemia.”
“ Sodium bicarbonate usage rates correlated inversely with the sites' intervals from collapse (r = - 0.579 P = 0.018) from initiation of ACLS (r = - 0.685 P = 0.003) and from first epinephrine (r = - 0.611 P = 0.012) to SB administration.”
“Sodium bicarbonate alone resulted in a modest increase in survival rate but this increased markedly when sodium bicarbonate was used with epinephrine or norepinephrine.”
“In mixtures alkalinised with sodium bicarbonate, epinephrine concentrations decreased significantly over 24 h (p<0.0001), whereas those in nonalkalinised mixtures did not change with time.”
“It is therefore generally assumed that epinephrine and sodium bicarbonate should not be infused in the same IV line during CPR.”
“Of these, 84 remained in refractory asystole after receiving epinephrine and sodium bicarbonate.”
“We hypothesized that EPI and NaHCO3 given during CPR have a significant impact on long term outcome.”
Epinephrine and sodium bicarbonate during CPR following asphyxial cardiac arrest in rats.“ Sodium bicarbonate combined with epinephrine tended to produce lower systemic blood pressure than other combinations.”
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