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Discover Supplement-Drug Interactions

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Last Updated: 2 months ago

Possible Interaction: Epinephrine and Sodium Bicarbonate



Research Papers that Mention the Interaction

Epinephrine concentration declined approximately 25% per week in anesthetic solution containing 100 meq/L sodium bicarbonate.
The pain of infiltrating lidocaine with epinephrine into skin is reduced by the addition of sodium bicarbonate.
The Journal of dermatologic surgery and oncology  •  1989  |  View Paper
Conversely, we must keep in mind that medical resuscitation using a beta-agonist drug epinephrine ) and sodium bicarbonate can induce transfer hypokalemia.
Critical Care  •  2017  |  View Paper
Sodium bicarbonate usage rates correlated inversely with the sites' intervals from collapse (r = - 0.579 P = 0.018) from initiation of ACLS (r = - 0.685 P = 0.003) and from first epinephrine (r = - 0.611 P = 0.012) to SB administration.
Acta anaesthesiologica Scandinavica  •  2005  |  View Paper
Sodium bicarbonate alone resulted in a modest increase in survival rate but this increased markedly when sodium bicarbonate was used with epinephrine or norepinephrine.
Toxicological reviews  •  2005  |  View Paper
In mixtures alkalinised with sodium bicarbonate, epinephrine concentrations decreased significantly over 24 h (p<0.0001), whereas those in nonalkalinised mixtures did not change with time.
Anaesthesia  •  2000  |  View Paper
It is therefore generally assumed that epinephrine and sodium bicarbonate should not be infused in the same IV line during CPR.
Annals of emergency medicine  •  1990  |  View Paper
Of these, 84 remained in refractory asystole after receiving epinephrine and sodium bicarbonate.
Annals of emergency medicine  •  1984  |  View Paper
We hypothesized that EPI and NaHCO3 given during CPR have a significant impact on long term outcome.
Resuscitation  •  1995  |  View Paper
Sodium bicarbonate combined with epinephrine tended to produce lower systemic blood pressure than other combinations.
Critical care medicine  •  1993  |  View Paper