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Discover Supplement-Drug Interactions
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Last Updated: 4 years ago
supplement:
Epinephrine
supplement:
Sodium Bicarbonate
Research Papers that Mention the Interaction
“The pain of infiltrating lidocaine with epinephrine into skin is reduced by the addition of sodium bicarbonate.”
Neutralized lidocaine with epinephrine for local anesthesia.“Nevertheless, medical resuscitation with beta‐agonist drug epinephrine ) and sodium bicarbonate may induce transfer hypokaliemia, with deleterious effect on membrane stabilization, sustaining VF.”
“Conversely, we must keep in mind that medical resuscitation using a beta-agonist drug epinephrine ) and sodium bicarbonate can induce transfer hypokalemia.”
“Sodium bicarbonate alone resulted in a modest increase in survival rate but this increased markedly when sodium bicarbonate was used with epinephrine or norepinephrine.”
“In mixtures alkalinised with sodium bicarbonate, epinephrine concentrations decreased significantly over 24 h (p<0.0001), whereas those in nonalkalinised mixtures did not change with time.”
“It is therefore generally assumed that epinephrine and sodium bicarbonate should not be infused in the same IV line during CPR.”
“Of these, 84 remained in refractory asystole after receiving epinephrine and sodium bicarbonate.”
“We hypothesized that EPI and NaHCO3 given during CPR have a significant impact on long term outcome.”
Epinephrine and sodium bicarbonate during CPR following asphyxial cardiac arrest in rats.“ Sodium bicarbonate combined with epinephrine tended to produce lower systemic blood pressure than other combinations.”
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