Possible Interaction: Epinephrine and Salicylic Acid

“Thus, both indomethacin and salicylate blunt the glycemic response to glucagon and glucagon plus epinephrine by attenuating glucose production and not by enhancing glucose utilization or insulin secretion.”

“The inhibitory effect of epinephrine (15 ng/kg/min) upon glucose-induced insulin secretion was partially reversed by sodium salicylate , an inhibitor of endogenous prostaglandin synthesis, which increased but not normalized, either the acute insulin response and the glucose disappearance rates.”

“At both doses of Epi, SS augmented the glucose disappearance rate (KG) after the glucose pulse (P < 0.001).”

“The lower dose of epinephrine diminished the acute insulin response (AIR) after a 20-g intravenous glucose pulse (control, 463 +/- 149; epinephrine, 97 +/- 38% of basal insulin, mean +/- SE, n = 6, P < 0.02); SS markedly augmented the AIR during epinephrine towards control values (339 +/- 137%; P < 0.02).”

“Abstract The inhibitory action … release inducible by epinephrine , comprising …, sodium salicylate , phenylbutazone and sulfinpyrazone—and other non-anti-inflammatory agents (NAA)—prostaglandin E 1 , adenosine, dipyridamole, methysergide and cyproheptadine—can … prior addition to human platelet rich plasma of the essential fatty acid, 5,8,11,14 eicosatetraenoic (arachidonic) acid.”

“The alpha adrenergic blocker phentolamine, but not salicylate poisoning, overcame the inhibitory effect of epinephrine on insulin secretion.”

“In the presence of epinephrine (5.5 microM) sodium salicylate (0.1 and 0.5 mM) reduced only the total number of heart beats.”

“The synergistic effects of the shear flow were also noted in the presence of adrenaline , which increased the release reaction, and when [Ca++] was raised above the physiological level or acetyl salicylic acid added, which inhibited the release of serotonin.”