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Last Updated: 3 months ago

Possible Interaction: Epinephrine and Ropivacaine

supplement:

Epinephrine

Research Papers that Mention the Interaction

Ropivacaine with epinephrine injection for postoperative analgesia is not recommended for this patient population.
Archives of otolaryngology--head & neck surgery  •  2004  |  View Paper
We conclude that epinephrine improves the pain relief and reduces the side effects of a thoracic epidural infusion of ropivacaine and fentanyl after major thoracic or upper abdominal surgery.
Anesthesia and analgesia  •  2002  |  View Paper
The addition of epinephrine to ropivacaine has not been recommended because ropivacaine has intrinsic vasoconstrictor properties.
We conclude that the addition of epinephrine 5 &mgr;g/mL to ropivacaine reduced the early systemic plasma concentrations of ropivacaine after epidural injection and may be useful for decreasing the risk of toxicity from systemic absorption of epidural ropivacaine.
Anesthesia and analgesia  •  2002  |  View Paper
Ropivacaine plain had a significantly shorter duration of pulpal anesthesia than ropivacaine with epinephrine.
Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics  •  2001  |  View Paper
The combination of ropivacaine and adrenaline did not accentuate but instead diminished the vasoconstrictive effect of epinephrine.
Regional Anesthesia & Pain Medicine  •  1992  |  View Paper
We postulated that addition of epinephrine 5 microg.mL(-1) to epidural ropivacaine would improve efficacy, decrease systemic absorption and reduce neonatal effects.
International journal of obstetric anesthesia  •  2002  |  View Paper
ropivacaine … adrenaline group were significantly lower than the controls from 10 to 90 min (P < 0.003 for each comparison), and the Cmax was less than …/mL versus 1.99 μg/mL, P < 0.001) with a longer Tmax (103.5 min versus 51.0 min, P = 0.001).
Anaesthesia and intensive care  •  2019  |  View Paper
The levels of epinephrine , norepinephrine, and cortisol were significantly lower in the ropivacaine group than in the control group at 24 and 48 h (P < 0.01 for all).
World journal of gastroenterology  •  2017  |  View Paper
Advanced age, malnutrition, epinephrine and possible elevation of α-1-acid glycoprotein levels could have altered the pharmacokinetics of plasma ropivacaine and possibly contributed to delayed neurotoxicity.
Canadian journal of anaesthesia = Journal canadien d'anesthesie  •  2007  |  View Paper
The addition of 5 &mgr;g/ml epinephrine to ropivacaine significantly delays its systemic absorption and reduces the peak plasma concentration.
Anesthesiology  •  2005  |  View Paper
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