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Discover Supplement-Drug Interactions

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Last Updated: 6 months ago

Possible Interaction: Epinephrine and Rolipram



Research Papers that Mention the Interaction

Cilostamide, but not rolipram , potentiated the effects of both (−)-noradrenaline and (−)-adrenaline.
Naunyn-Schmiedeberg's Archives of Pharmacology  •  2006  |  View Paper
After 4 h of incubation in the presence of adrenaline , inhibition of cAMP degradation by rolipram further increased cAMP levels by about 300% and also enhanced PDE4 activity.
Archives of Dermatological Research  •  2002  |  View Paper
Intraperitoneal administration of the phosphodiesterase type 4 (PDE4) inhibitor rolipram (1-30 mg/kg) caused a dose-dependent increase in the circulating levels of both corticosterone and adrenaline in male Balb/c mice.
These data suggest the release of both corticosterone and adrenaline contribute to the ability of rolipram to inhibit TNF-alpha production in mouse blood ex vivo.
Cytokine  •  1997  |  View Paper