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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Epinephrine
drug:
Rolipram
Research Papers that Mention the Interaction
“Cilostamide, but not rolipram , potentiated the effects of both (−)-noradrenaline and (−)-adrenaline.”
Cilostamide potentiates more the positive inotropic effects of (−)-adrenaline through β2-adrenoceptors than the effects of (−)-noradrenaline through β1-adrenoceptors in human atrial myocardium“After 4 h of incubation in the presence of adrenaline , inhibition of cAMP degradation by rolipram further increased cAMP levels by about 300% and also enhanced PDE4 activity.”
“Intraperitoneal administration of the phosphodiesterase type 4 (PDE4) inhibitor rolipram (1-30 mg/kg) caused a dose-dependent increase in the circulating levels of both corticosterone and adrenaline in male Balb/c mice.”
“These data suggest the release of both corticosterone and adrenaline contribute to the ability of rolipram to inhibit TNF-alpha production in mouse blood ex vivo.”
The inhibitory effect of rolipram on TNF-alpha production in mouse blood ex vivo is dependent upon the release of corticosterone and adrenaline.
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