Possible Interaction: Epinephrine and Rilmenidine

“Although the hypotensive effect of rilmenidine was not remarkable in the dose range we tested, rilmenidine increased the arrhythmogenic threshold for epinephrine in a dose-dependent manner during halothane anesthesia, achieving statistical significance at 10 $mUg/kg> the highest dose we examined.”

“In conscious rabbits, rilmenidine 0.1, 0.3 and 1.0 mg kg-1 dose-dependently lowered blood pressure, renal sympathetic nerve activity, heart rate and the plasma concentration of noradrenaline and adrenaline.”

“Drug inhibition studies revealed that specific binding of [3H]rilmenidine (2 nM) was only inhibited by a maximum of 50% by the catecholamines, adrenaline and noradrenaline, but was completely inhibited by some oxazolines, by guanabenz (a guanidino drug) and by several imidazoline compounds including naphazoline, oxymetazoline and clonidine.”