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Discover Supplement-Drug Interactions

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Last Updated: 3 years ago

Possible Interaction: Epinephrine and Rilmenidine



Research Papers that Mention the Interaction

Although the hypotensive effect of rilmenidine was not remarkable in the dose range we tested, rilmenidine increased the arrhythmogenic threshold for epinephrine in a dose-dependent manner during halothane anesthesia, achieving statistical significance at 10 $mUg/kg> the highest dose we examined.
Journal of cardiovascular pharmacology  •  1995  |  View Paper
In conscious rabbits, rilmenidine 0.1, 0.3 and 1.0 mg kg-1 dose-dependently lowered blood pressure, renal sympathetic nerve activity, heart rate and the plasma concentration of noradrenaline and adrenaline.
Naunyn-Schmiedeberg's archives of pharmacology  •  1993  |  View Paper
Drug inhibition studies revealed that specific binding of [3H]rilmenidine (2 nM) was only inhibited by a maximum of 50% by the catecholamines, adrenaline and noradrenaline, but was completely inhibited by some oxazolines, by guanabenz (a guanidino drug) and by several imidazoline compounds including naphazoline, oxymetazoline and clonidine.
European journal of pharmacology  •  1992  |  View Paper