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Last Updated: 2 months ago

Possible Interaction: Epinephrine and Quinidine

supplement:

Epinephrine

supplement:

Quinidine

Research Papers that Mention the Interaction

Epinephrine infusion, at both 25 and 50 ng/kg per min, completely reversed the effects of quinidine and partially reversed the effects of amiodarone on the effective refractory period.
Journal of the American College of Cardiology  •  1992  |  View Paper
Epinephrine partially or completely reversed the effects of quinidine on ventricular refractory periods, but had no effect on QRS duration.
Journal of the American College of Cardiology  •  1988  |  View Paper
In vitro, quinidine produces platelet swelling and inhibits aggregation of platelets by adenosine diphosphate, epinephrine , and collagen.
The Journal of clinical investigation  •  1972  |  View Paper
Quinine and quinidine antagonize the cardioaccelerator action of epinephrine in the heart-lung preparation of the dog.
The Journal of pharmacology and experimental therapeutics  •  1950  |  View Paper
Quinidine (10 mg/kg, i.v.) was effective in this test and also antagonized the pressor response induced by epinephrine.
Nihon yakurigaku zasshi. Folia pharmacologica Japonica  •  1984  |  View Paper
Epinephrine caused a partial reversal of the reduction of phase 4 slope produced by quinidine.
The Journal of pharmacology and experimental therapeutics  •  1976  |  View Paper
Quinacrine and quinidine (0·1−1·0 mM) inhibited the activation of adenylate cyclase activity in fat cell ghosts due to glucagon or epinephrine.
Biochemical pharmacology  •  1973  |  View Paper