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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Epinephrine
drug:
Quinacrine
Research Papers that Mention the Interaction
“Furthermore, whereas U73122 abolished the effects of epinephrine, quinacrine only prevented the effects of epinephrine , suggesting that AA release through PLC and its metabolites are responsible for MAPK and Akt activation by alpha(2)-ARs.”
alpha(2)-Adrenergic receptors activate MAPK and Akt through a pathway involving arachidonic acid metabolism by cytochrome P450-dependent epoxygenase, matrix metalloproteinase activation and subtype-specific transactivation of EGFR.“In addition, epinephrine increased AA release and PGE2 production and effects of epinephrine on alpha-MG uptake and AA release were blocked by staurosporine and bisindolylmaleimide I or mepacrine and AACOCF3.”
Effect of epinephrine on alpha-methyl-D-glucopyranoside uptake in renal proximal tubule cells.“The effects of adrenaline , prostaglandin E2, dibutyryl cyclic AMP (DBcAMP) and the Ca ionophore A23187 were inhibited by mepacrine , trifluoperazine and bumetanide.”
“Daily injection of quinacrine (16 mg/kg), an antimalarial agent that inhibits phospholipase A2, blocked the subsensitivity to the chronotropic effect of epinephrine , but not that to the pressor effect of epinephrine.”
“ Quinacrine and quinidine (0·1−1·0 mM) inhibited the activation of adenylate cyclase activity in fat cell ghosts due to glucagon or epinephrine.”
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