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Discover Supplement-Drug Interactions

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Last Updated: 2 months ago

Possible Interaction: Epinephrine and Prilocaine



Research Papers that Mention the Interaction

BACKGROUND Prilocaine has been described as causing less pain on injection than lidocaine with epinephrine , possibly because of the higher pH of the prilocaine anesthetic solution.
Journal of the American Dental Association  •  2001  |  View Paper
In comparison with the placebo, the application of ropivacaine 0.5% and 0.75%, as well as prilocaine 0.5% with epinephrine 1:200,000, caused a significant reduction in tail temperature (P < .001 at t = 20, 30, and 40 minutes).
Prilocaine 0.5% with epinephrine 1:200,000 reduced blood flow by up to 44.7% (t = 20 minutes, P < .001).
Regional Anesthesia & Pain Medicine  •  2007  |  View Paper