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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Epinephrine
drug:
Practolol
Research Papers that Mention the Interaction
“Pindolol, but not practolol , inhibits these adrenaline‐induced changes in platelet behaviour.”
Adrenaline infusion evokes increased thromboxane B2 production by platelets in healthy men: the effect of beta‐adrenoceptor blockade“…,(±)-pindolol (10–5 mol/l) weakly … catecholamines ((–)-isoprenaline, (–)-noradrenaline and (–)-adrenaline ), a selective β3-adrenoceptor agonist BRL37344 ((R*,R*)-(±)-4-[2-[(2-(3-chlorophenyl)-2-hydroxyethyl)amino]propyl]phenoxyacetic acid …-adrenoceptor agonist (±)-CGP12177A ([4-[3-[(1,1-dimethylethyl)amino]-2-hydroxypropoxy]-1,3-dihydro-2H-benzimidazol-2-one] hydrochloride).”
Partial Agonistic Properties of (±)-Pindolol at Atypical β-Adrenoceptors in the Guinea Pig Gastric Fundus“Also, the administration of (−)-epinephrine significantly increased the phosphorylase b to a conversion in ischemic tissue over the nonischemic tissue and this conversion was blocked by pretreatment with (±)-propranolol.”
“The adrenergic beta-receptor blockers: Propranolol, Alprenolol, Oxprenolol, Pindolol, Practolol , and Talinolol, inhibit the calorigenic action of adrenaline in experiments on rats.”
“Nevertheless, the beta(1)- and beta(2)-antagonist, propranol, and the beta(1)-antagonist, practolol , blocked the increment in CLE accumulation produced by epinephrine ; the alpha-antagonist, phentolamine, was without effect.”
“In preparations driven at 1 Hz, practolol antagonized the effect of adrenaline at concentration above 3 X 10(-8) M without affecting the curve at lower concentrations, the beta-blocker competitively anatagonized the effect of the agonist at 2.5 Hz.”
“ Epinephrine and norepinephrine produced a decrease in the coronary flow after practolol which completely abolished the increase in the myocardial O2 consumption as well as the positive inotropic and chronotropic effects produced by these compounds, while isoproterenol and salbutamol produced an increase.”
“: The β-adrenoceptor blocking agents (±)-practolol , (±)-propranolol, (—)-propranolol and (±)-sotalol were found to reduce the adrenaline induced inhibition of carrageenin-induced rat paw oedema during the first hour of development and then potentiate adrenaline for at least 3 hours.”
“4 Propranolol, acebutolol and practolol were all effective in decreasing the frequency of ectopic beats induced by adrenaline and methylchloroform in the anaesthetized cat.”
“ Practolol , a β-adrenergic antagonist, inhibited the accumulation of cyclic AMP induced by epinephrine , but not induced by histamine.”
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