Possible Interaction: Epinephrine and Potassium

“… epinephrine-containing local anesthetic … the plasma potassium concentration 10 min after injection, by 0.16 +/- 0.20 mmol/L (mean +/- SD), and increased the blood glucose concentration at …, 20, and 30 min (by 0.46 +/- 0.37, 0.63 +/- 0.45, and 0.56 +/- 0.28 mmol/L, respectively).”

“Thus, ADR caused dose-dependent shifts of digoxin and potassium , whereas mental stress failed to do so, possibly due to a modest ADR response and small increases in sympathetic nerve activity in skeletal muscle.”

“ Adrenaline significantly reduced plasma potassium levels following placebo and CGP pretreatment but plasma potassium was unaltered by adrenaline with metoprolol and propranolol pretreatment.(ABSTRACT TRUNCATED AT 250 WORDS)”

“ Epinephrine inhibits potassium secretion at sites beyond the distal tubule.”

“Infusion of adrenaline into healthy male subjects reduced the plasma concentrations of both potassium and phosphate to a similar extent, in a dose-dependent manner, an effect which was prevented by the administration of propranolol.”

“Serum concentrations of calcium, magnesium, potassium and phosphate can be lowered experimentally by adrenaline , which also can stimulate the secretion of parathyroid hormone (PTH).”

“A decrease in the arterial potassium concentration was observed during infusion of adrenaline and is in conformity with previous studies.”

“The enhancing effect of epinephrine on extrarenal potassium uptake was completely reversed with the beta-blocking agent propranolol.”

“The administration of epinephrine may have produced greater uptake of potassium by muscle in these patients than in normal subjects, but the difference was less marked than in the case of glucose.”

“Evidence that epinephrine and insulin induced a rapid and significant fall in plasma potassium level in man and animals has been reported by several investigators (Houssay et al., 1937; D'Silva, 1937; Flocks et al., 1939; Keys, 1938a, 1938b; ...”