Possible Interaction: Epinephrine and Potassium Chloride

“The change in plasma epinephrine concentration following KCl injection was significant (P less than 0.01).”

“ Epinephrine infusion with potassium chloride markedly inhibited the urinary excretion of potassium (UkV) to rates that were actually below the basal potassium excretion rate (P less than 0.001).”

“The epinephrine infusion with potassium chloride led to a marked improvement in potassium tolerance, which was due to a greater than twofold increase in the extrarenal disposal of potassium (P less than 0.001).”

“An accelerating tachycardia ending in fibrillation can be initiated in isolated hearts by injections of KCl after the administration of epinephrine , but not in untreated hearts.”

“In group II rats, which received a similar dose of KCl but with epinephrine , the increase in PK (delta = 0.8 meq/liter, P less than 0.001) was blunted and UKV was reduced (delta = 0.23 mueq/min, P less than 0.001).”

“4) Epinephrine , in a dose (1 to 2 μg/ml) which markedly augments twitch tension, profoundly decreases tension developed by the same preparation during a potassium chloride contracture ; this is the case for both the frog ventricle strip and the cat papillary muscle.”