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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
supplement:
Epinephrine
drug:
Pindolol
Research Papers that Mention the Interaction
“SummaryTo investigate if the intrinsic sympathomimetic activity of pindolol could modify its beta-blocking effects on the responses to an adrenaline infusion , 10 healthy volunteers were studied.”
Effects of atenolol and pindolol on the hypokalaemic and cardiovascular responses to adrenaline infusion“The threshold values of ADP and adrenaline for irreversible platelet aggregation were significantly higher for pindolol and metoprolol than for propranolol.”
“Propranolol and pindolol reduced myocardial oxygen demand estimated by the HR x BP product after EPI , but this response was abolished by atropine.”
“ Pindolol blunted markedly the effects of adrenaline on platelet TxB2 production, whereas practolol seemed to have only a weak effect.”
“ Pindolol , but not practolol, inhibits these adrenaline‐induced changes in platelet behaviour.”
“ Pindolol treatment also resulted in a significantly higher adrenaline level at exhaustion.”
“Plasma adrenaline concentration was significantly raised by pindolol only during maximal exercise (from 3.1 ± 1.6 to 5.6 ± 4.0 pmoles/ml, p < 0.05).”
“These results suggest that pindolol blocked both beta 1 and beta 2 receptors, and therefore, this resulted in exaggerated alpha effects of epinephrine , a remarkable systemic vasoconstriction, and pulmonary congestion.”
“We found that: (1) …; (2) in SHR, epinephrine … pindolol induced remarkable hemodynamic changes (in particular, increase in diastolic blood pressure), which were prevented by phentolamine pretreatment, whereas epinephrine with … combination with pindolol caused pulmonary congestion or edema in SHR; this was confirmed by both quantitative analysis and histological investigations.”
“We conclude that epinephrine activates the left ventricular relaxation rate but impairs it in the presence of pindolol.”
“Plasma adrenaline concentration was significantly raised only by pindolol during maximal exercise (from 3.9 ± 2.3 to 5.0 ± 3.3 nmol/L, p < 0.05).”
“The potent β -blockers pindolol was less inhibitory than propranolol when adrenaline and ADP were used to induce platelet aggregation.”
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