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Last Updated: 2 months ago

Possible Interaction: Epinephrine and Pindolol

supplement:

Epinephrine

Research Papers that Mention the Interaction

Propranolol and pindolol reduced myocardial oxygen demand estimated by the HR x BP product after EPI , but this response was abolished by atropine.
Journal of cardiovascular pharmacology  •  1992  |  View Paper
We conclude that epinephrine activates the left ventricular relaxation rate but impairs it in the presence of pindolol.
Anesthesia progress  •  1996  |  View Paper
These results suggest that pindolol blocked both beta 1 and beta 2 receptors, and therefore, this resulted in exaggerated alpha effects of epinephrine , a remarkable systemic vasoconstriction, and pulmonary congestion.
We found that: (1) …; (2) in SHR, epinephrine … pindolol induced remarkable hemodynamic changes (in particular, increase in diastolic blood pressure), which were prevented by phentolamine pretreatment, whereas epinephrine with … combination with pindolol caused pulmonary congestion or edema in SHR; this was confirmed by both quantitative analysis and histological investigations.
Research communications in chemical pathology and pharmacology  •  1993  |  View Paper
Intravenous arotinolol (> 3 micrograms/kg), propranolol (> 30 micrograms/kg) and pindolol (> 3 micrograms/kg) blocked the effects of isoproterenol and epinephrine , but atenolol (-300 micrograms/kg), prazosin (0.1-10 micrograms/kg) and phentolamine (10, 30 micrograms/kg) did not block them.
Nihon yakurigaku zasshi. Folia pharmacologica Japonica  •  1993  |  View Paper
The hyperglycaemic effect of TET like that of epinephrine could be prevented by the administration of 1 mg/kg of the beta blocker, pindolol.
Acta physiologica Academiae Scientiarum Hungaricae  •  1979  |  View Paper