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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Epinephrine
drug:
Physostigmine
Research Papers that Mention the Interaction
“Cholinergic stimulation of the hypothalamic‐pituitary‐adrenal axis and adrenal medulla by physostigmine enhances secretion of arginine vasopressin, epinephrine , and norepinephrine.”
Physostigmine Prevents Postanesthetic Shivering As Does Meperidine or Clonidine“Administration of physostigmine , unlike that of neostigmine, was associated with statistically significant increases in plasma concentrations of cortisol, prolactin, ACTH, beta-endorphin/beta-lipotropin-like immunoreactivity, and epinephrine , presumably via central mechanisms.”
“ Physostigmine promptly increased plasma arginine vasopressin (tenfold), beta-endorphin (twofold to threefold) and epinephrine (threefold) levels in elderly control subjects.”
“A dose of 0.022 mg/kg physostigmine dramatically increased plasma epinephrine levels and slightly increased norepinephrine levels, which is consistent with selective adrenomedullary stimulation.”
“ConclusionsThese results suggest that physostigmine worsens ischemic outcome by a mechanism that is associated with increases in plasma epinephrine and norepinephrine.”
“ResultsCompared to control rats, physostigmine increased plasma epinephrine and norepinephrine 10-fold and worsened neurologic outcome.”
Sympathetic Stimulation with Physostigmine Worsens Outcome from Incomplete Brain Ischemia in Rats“Phenylephrine, adrenaline and dopamine markedly inhibited pressure responses to physostigmine , while the responses to acetylcholine were impaired to a less extent.”
“The anticholinesterase physostigmine decreased hypothalamic epinephrine concentrations and this effect was blocked by the centrally acting nicotinic antagonist mecamylamine, but not by hexamethonium, scopolamine or methscopolamine.”
“Although physostigmine produced marked glycogenolysis in the control dogs it significantly inhibited cardiac glycogenolysis after light petroleum plus adrenaline , atrial glycogenolysis after strophanthin‐K‐induced arrhythmias and ventricular glycogenolysis after myocardial ischaemia.”
“Further, combined administration of adrenaline and physostigmine , both of which otherwise activated the heart enzyme, resulted in an inhibition of the enzyme activity.”
THE EFFECT OF PHYSOSTIGMINE ON HEART PHOSPHORYLASE ACTIVITY IN THE SPINAL RAT.
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