Possible Interaction: Epinephrine and Phospholipids

“Thrombin, epinephrine and adenine potently inhibit phospholipid methylation and to a lesser degree enhance degradation of 3 H-methylated phospholipids.”

“Other agonists such as epinephrine , adenosine diphosphate (ADP), or A23187 also decreased phospholipid methylation under conditions in which they stimulated serotonin release.”

“In the presence of epinephrine , cellular triacylglycerol and total phospholipids were slightly but significantly higher than the respective control at all points of time examined.”

“… epinephrine appeared at concentrations of more than 1 microM and reached a plateau at 100 microM. Epinephrine concentration for the half of the maximal … suppressed the secretion of triacylglycerol by 33% (P<or=0.01) and increased cellular content of triacylglycerol (18%, P<or=0.05) and total phospholipids (…).”

“The results show that both ageing and epinephrine administration simultaneously modify the fatty acid composition of membrane phospholipids and the binding properties of alpha 1- and beta-adrenoceptors in rat heart.”

“ Epinephrine and acetylcholine stimulated phospholipid but not cholesterol release.”

“As the epinephrine dose increased the linoleic acid content of the hepatic phospholipids increased and the arachidonic acid decreased at 96 h after hepatectomy.”

“The results demonstrate that repeated administration of epinephrine caused significant alterations in fatty acid composition of major phospholipids in heart muscle of rats fed diets enriched with either butter, corn oil, or cod liver oil.”

“In platelets prelabelled with [32P]Pi and [3H]glycerol, adrenaline was found to potentiate the ADP-induced changes in platelet phospholipids , causing larger increases in the amount and labelling of phosphatidylinositol 4-phosphate (PIP) and phosphatidic acid than was observed with ADP alone.”

“ Epinephrine also increased phospholipid methylation.”

“Carbamylcholine and epinephrine stimulated 32P incorporation into both of these phospholipids , causing their half-maximal effects at 2 and 0.8 microM respectively.”