Possible Interaction: Epinephrine and Phenylephrine

“Cardiac output remained unchanged in patients receiving low-dose epinephrine but declined significantly in patients receiving phenylephrine ( p = 0.0001).”

“ Phenylephrine , the prototype alpha-agonist, did not induce aggregation but was a potent inhibitor (Ki approximately 12 microM) of the aggregation induced by epinephrine.”

“ Epinephrine is found to be 19 and 29 times more potent than those of methoxamine and L-phenylephrine , respectively.”

“Inhibition of NO formation by l-NMMA as well as phenylephrine infusion caused decreases in the plasma clearance of noradrenaline and adrenaline which were correlated with the drug-induced decreases in cardiac output.”

“This effect of epinephrine was mimicked by phenylephrine , but not by clonidine, dobutamine, or salbutamol, and it was inhibited by phentolamine, but not by propranolol.”

“Norepinephrine and epinephrine (both α and β agonists) also stimulated GSH absorption but not to the same extent as phenylephrine.”

“During the delayed recovery phase of phenylephrine, adrenaline preserved its ability to suppress the spontaneous electrical and mechanical activities of the taenia both when phenylephrine was replaced by adrenaline or when adrenaline was applied in addition to phenylephrine.”

“Ganglionectomized eyes received much lower drug concentrations (0·1% in all cases), and displayed a different order of responsiveness: phenylephrine caused a larger reduction in flow than epinephrine , and norepinephrine failed to provoke statistically significant change.”

“When adrenaline of alpha-phenylephrine was administered, the CGT cells degranulated, and there was a concomitant loss of intracellular EGF-positive immunofluorescence.”

“In rat adrenal glands incubated in Locke's solution in vitro norepinephrine and phenylephrine inhibited the release of epinephrine.”