Possible Interaction: Epinephrine and Phenylalanine

“High Phe concentrations interfere with the production of adrenaline (A), noradrenaline (NA), and dopamine (DA) (1)(3).”

“The impaired conversion of phenylalanine may affect not only the production of tyrosine but also the biosynthesis of the neurotransmitters dopamine, norepinephrine and epinephrine.”

“Infusion of epinephrine (plasma concentration: approximately 3600 pmol/L) decreased leucine and phenylalanine and increased ketoisocaproate plasma concentrations and increased the metabolic clearance rate of leucine and phenylalanine.”

“…,epinephrine induced significant increases in forearm blood flow (P < 0.01) and net lactate … < 0.01) at both 2 and 4 h. At 2 and 4 h phenylalanine release from muscle proteolysis was suppressed (P < 0.01), and at … (P < 0.02), indicating an anticatabolic effect on muscle protein.”

“ Epinephrine reduced, by about 30%, the mucosal transport of phenylalanine by activating alpha 1, alpha 2, and beta adrenergic receptors.”

“ Adrenaline , carbamoylcholine, phenylephrine and ionophore A23187 inhibited the incorporation of [3H]phenylalanine into acid-insoluble protein; isoprenaline, dibutyryl cyclic AMP and 8-bromo-cyclic GMP were inactive.”