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Discover Supplement-Drug Interactions

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Last Updated: 2 months ago

Possible Interaction: Epinephrine and Phenylalanine





Research Papers that Mention the Interaction

High Phe concentrations interfere with the production of adrenaline (A), noradrenaline (NA), and dopamine (DA) (1)(3).
Clinical chemistry  •  2002  |  View Paper
The impaired conversion of phenylalanine may affect not only the production of tyrosine but also the biosynthesis of the neurotransmitters dopamine, norepinephrine and epinephrine.
Journal of the Neurological Sciences  •  2013  |  View Paper
Infusion of epinephrine (plasma concentration: approximately 3600 pmol/L) decreased leucine and phenylalanine and increased ketoisocaproate plasma concentrations and increased the metabolic clearance rate of leucine and phenylalanine.
The American journal of clinical nutrition  •  1997  |  View Paper
…,epinephrine induced significant increases in forearm blood flow (P < 0.01) and net lactate … < 0.01) at both 2 and 4 h. At 2 and 4 h phenylalanine release from muscle proteolysis was suppressed (P < 0.01), and at … (P < 0.02), indicating an anticatabolic effect on muscle protein.
The American journal of physiology  •  1995  |  View Paper
Epinephrine reduced, by about 30%, the mucosal transport of phenylalanine by activating alpha 1, alpha 2, and beta adrenergic receptors.
Canadian journal of physiology and pharmacology  •  1997  |  View Paper
Adrenaline , carbamoylcholine, phenylephrine and ionophore A23187 inhibited the incorporation of [3H]phenylalanine into acid-insoluble protein; isoprenaline, dibutyryl cyclic AMP and 8-bromo-cyclic GMP were inactive.
The Biochemical journal  •  1978  |  View Paper