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Possible Interaction: Epinephrine and Phenoxybenzamine

Research Papers that Mention the Interaction

Phenoxybenzamine prevented vasoconstriction in response to epinephrine , dopamine, and phenylephrine, with its effect lasting at least 5 hours.
The Journal of thoracic and cardiovascular surgery  •  2003  |  View Paper
Phenoxybenzamine , an alpha-adrenoceptor antagonist, canceled this potentiation by epinephrine.
Journal of biochemistry  •  1997  |  View Paper
Alpha-receptor blocking agents, phenoxybenzamine and indoramine, showed an inhibition of the contraction induced with both epinephrine and norepinephrine.
European journal of respiratory diseases  •  1980  |  View Paper
phenoxybenzamine , an adrenergic blocking agent, had no effect … the decrease which follows administration of epinephrine ; this was probably due to a central effect, as experiments designed to eliminate local effects of the … themselves or their blood supply suggested that depression of the index was mediated through central nervous mechanisms.
The American journal of physiology  •  1963  |  View Paper
Systemically administered phenoxybenzamine prevented the mydriasis induced by intraocular d - or l -epinephrine, d -or i -nor epinephrine , and l -isoproterenol.
The Journal of pharmacology and experimental therapeutics  •  1961  |  View Paper
Dibozane and phenoxybenzamine antagonized the vasoconstriction caused by epinephrine but not its cardias effects.
The Journal of pharmacology and experimental therapeutics  •  1965  |  View Paper
Drugs such as phenoxybenzamine that block alpha receptors antagonize the constrictor action of norepinephrine and epinephrine and potentiate the vasodilator effect of epinephrine but not that of isoproterenol (4, 7, 8).
The Journal of clinical investigation  •  1964  |  View Paper
Phenoxybenzamine effectively blocks the vasopressor response to norepinephrine and epinephrine , and ergotamine produces maximal reversal of epinephrine.
The Journal of pharmacology and experimental therapeutics  •  1961  |  View Paper
Pretreatment of rats with the α-adrenergic antagonist, phenoxybenzamine , enhanced the effect of epinephrine while pretreatment with the β-antagonist, propranolol, reduced the effect of isoproterenol.
Calcified Tissue Research  •  2007  |  View Paper
Epinephrine infusion produced a dose-dependent increase in Rv (EC50=5.3·10-7M), which could be reversed by sodium nitroprusside (a smooth muscle relaxant) and blocked by phenoxybenzamine (an α-adrenergic antagonist).
Journal of Comparative Physiology B  •  2004  |  View Paper
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