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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Epinephrine
drug:
Pentobarbital
Research Papers that Mention the Interaction
“The inotropic response to epinephrine was blocked by pentobarbital.”
The influence of pentobarbital on the inotropic responses of the isolated frog heart to epinephrine and acetylcholine.“The probable involvement of brain epinephrine in the expression of the acute sedative and intoxicating effects of ethanol and pentobarbital is demonstrated.”
Antagonism of ethanol intoxication in rats by inhibitors of phenylethanolamine N-methyltransferase.“Pretreatment with pentobarbital inhibited the Shosaikoto-induced decrease of plasma AD levels.”
“Significantly shorter periods of arrhythmia after each dose of epinephrine were seen in rats anesthetized with pentobarbital than were seen in rats anesthetized with halothane.”
“In adult male rats anaesthetized with pentobarbital , intravenous infusion of 0.25 microgram kg-1 min-1 of epinephrine increased plasma epinephrine levels to more than 10 pmol ml-1 within 5 min, the values remaining constant during the next 20 min.”
“The reductions in the hypothalamic and brainstem EPI concentrations in rats anesthetized with pentobarbital sodium were accompanied by parallel increases in blood glucose.”
“In untrained … venipuncture, pentobarbital (30 mg/kg … plasma concentration of epinephrine (E) from 146 +/- 9 to 38 +/- 8 (SE) pg/ml (n = 46) and norepinephrine (NE) from 276 +/- 13 to …/ml (both P less than 0.0005), suggesting that barbiturate anesthesia suppresses sympathetic outflow in these mildly stressed animals.”
“ Pentobarbital inhibited the incorporation of 3H equally in the presence and absence of epinephrine , indicating that the effect of pentobarbital on 32P incorporation is on turnover and not on de novo synthesis.”
“5 In experiments performed under pentobarbitone anaesthesia, the intravenous injection of adrenaline (5 microgram) or salbutamol (0.5 to 50 microgram) led to a rapid and marked increase in the EM of the exposed soleus muscle.”
“… PTB can: a) … by epinephrine , serotonin, and KC1; c) cause a noncompetitive type displacement of the dose response curves of these vasoactive agents; d) attenuate Ca2+- induced … dose-response curves to the right; and e) rapidly relax drug as well as Ca2+ -induced contractions of aortas and portal veins.”
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