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Discover Supplement-Drug Interactions
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Last Updated: 4 years ago
supplement:
Epinephrine
drug:
Papaverine
Research Papers that Mention the Interaction
“When puerarin and papaverin were given intravenously to mice at the dosages of 52 and 10 mg/kg respectively, both showed protective effects on the microcirculatory disturbance induced by adrenaline administered locally 5 min later.”
[Beneficial effect of puerarin on experimental microcirculatory disturbance in mice].“ (-)-Epinephrine (3 microM) potentiation of adenosine diphosphate (ADP, 0.1 microM) aggregation was inhibited by papaverine with IC50 of 11 +/- 3.6 microM (n = 4).”
“ Papaverine showed a non competitive antagonism against epinephrine but was ineffective against Ca2+; verapamil antagonized both the action of epinephrine and Ca2+ in a different manner but at the same concentrations.”
“ Papaverine and kallicrein raise the level of epinephrine and reduce the concentration of norepinephrine.”
“Antagonism by papaverine or theophylline was increased by prior or simultaneous treatment with salbutamol, isoproterenol, epinephrine , or norepinephrine.”
“ Papaverine potentiated the relaxinf effects of adrenaline both when administered alone and in combination with propranolol or with phentolamine.”
“Isoproterenol, epinephrine , prostaglandins E1, E2, or F2α produced further increases of cAMP in the presence of papaverine.”
“The superprecipitation increasing effect of adrenaline and histamine were inhibited by papaverine , nitrite and flufenamic acid in very low concentrations.”
“ Adrenaline partially and neostigmine completely abolished the inhibition or blockade evoked by papaverine.”
“In rat diaphragm, papaverine increased glycogenolysis to the same extent as epinephrine and had a synergistic effect with epinephrine on glycogen breakdown.”
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