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Discover Supplement-Drug Interactions
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Last Updated: 2 months ago
supplement:
Epinephrine
drug:
Oxymetazoline
Research Papers that Mention the Interaction
“Addition of epinephrine in concentrations of 1:50,000 or 1:200,000 increases duration of analgesia after local infiltration by approximately 200%.”
Epinephrine Prolongs Duration of Subcutaneous Infiltration of Local Anesthesia in a Dose-related Manner:: Correlation With Magnitude of Vasoconstriction“By causing vasoconstriction, epinephrine complements the local analgesic by prolonging the duration of action and providing a temporary hemostatic effect.”
“ Epinephrine added to local anaesthetics enhances the analgesia, hastens the onset and prolongs the duration of action, and may cause a more dense block.”
“Adding epinephrine , clonidine or dexmedetomidine, but only as a single dose, results in a faster onset, longer duration of action and increased intensity of neuronal blockade of regional anaesthesia.”
[Background and current use of adjuvants for regional anesthesia : From research to evidence-based patient treatment].“ Epinephrine is often added at 1:100,000 or 1:200,000 to constrict blood vessels, thus prolonging the duration of anesthesia.”
“Furthermore, cirazoline and oxymetazoline were able to displace the dose-response curve to epinephrine in rat hepatocytes, i.e., they behaved as antagonists.”
Differential effects of adrenergic agonists and phorbol esters on the alpha 1-adrenoceptors of hepatocytes and aorta.
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