Allen Institute for Artificial Intelligence logo

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 months ago

Possible Interaction: Epinephrine and Oxymetazoline



Research Papers that Mention the Interaction

Addition of epinephrine in concentrations of 1:50,000 or 1:200,000 increases duration of analgesia after local infiltration by approximately 200%.
Regional Anesthesia & Pain Medicine  •  1994  |  View Paper
By causing vasoconstriction, epinephrine complements the local analgesic by prolonging the duration of action and providing a temporary hemostatic effect.
Annals of plastic surgery  •  1998  |  View Paper
Epinephrine added to local anaesthetics enhances the analgesia, hastens the onset and prolongs the duration of action, and may cause a more dense block.
Canadian journal of anaesthesia = Journal canadien d'anesthesie  •  1996  |  View Paper
Adding epinephrine , clonidine or dexmedetomidine, but only as a single dose, results in a faster onset, longer duration of action and increased intensity of neuronal blockade of regional anaesthesia.
Der Anaesthesist  •  2019  |  View Paper
Epinephrine is often added at 1:100,000 or 1:200,000 to constrict blood vessels, thus prolonging the duration of anesthesia.
Journal of the American Academy of Dermatology  •  2016  |  View Paper
Furthermore, cirazoline and oxymetazoline were able to displace the dose-response curve to epinephrine in rat hepatocytes, i.e., they behaved as antagonists.
European journal of pharmacology  •  1985  |  View Paper