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Regional Anesthesia & Pain Medicine • 1994 | View Paper
“By causing vasoconstriction, epinephrine complements the local analgesic by prolonging the duration of action and providing a temporary hemostatic effect.”
“ Epinephrine added to local anaesthetics enhances the analgesia, hastens the onset and prolongs the duration of action, and may cause a more dense block.”
Canadian journal of anaesthesia = Journal canadien d'anesthesie • 1996 | View Paper
“Adding epinephrine , clonidine or dexmedetomidine, but only as a single dose, results in a faster onset, longer duration of action and increased intensity of neuronal blockade of regional anaesthesia.”
Journal of the American Academy of Dermatology • 2016 | View Paper
“Furthermore, cirazoline and oxymetazoline were able to displace the dose-response curve to epinephrine in rat hepatocytes, i.e., they behaved as antagonists.”