Possible Interaction: Epinephrine and Nitroprusside

“BothAS and SNP significantly inhibited platelet aggregation and ATP release induced by different agonists and adrenaline.”

“The staurosporine-insensitive aggregation was strongly potentiated by adrenaline, an alpha 2-adrenergic agonist; adrenaline also counteracted the inhibition induced by prostacyclin and nitroprusside , with no appreciable effect on the cAMP levels and on the cyclic nucleotide-dependent protein phosphorylation.”

“Yohimbine and NIP increased and PRO + EPI and methoxamine decreased NE FSO, without effects on systemic blood pressure, heart rate, or arterial levels of catechols.”

“During sodium nitroprusside infusion, the number of circulating platelet aggregates declined to normal levels and in vitro platelet aggregation responses to epinephrine and adenosine diphosphate were also suppressed significantly (p < 0.01).”

“The addition of epinephrine to sodium nitroprusside –enhanced cardiopulmonary resuscitation during cardiopulmonary resuscitation reduced its improvement in heat exchange.”

“ Epinephrine (30μg) reversed the effects of SNP and significantly shortened the duration of peak action and total effect (P<0.05).”

“The combined infusion of nitroprusside and epinephrine , unless ISVR was elevated, produced synergistic effects on PV, MA, VTI, and minute distance.”

“ Sodium nitroprusside (10(-6) M) inhibited effluxes of norepinephrine and epinephrine and 3-morpholinosydnonimine had no effect on these effluxes.”

“During hypotension induced by sodium nitroprusside and nicardipine, plasma epinephrine was significantly higher than the control value.”

“Moreover, decreasing blood pressure with sodium nitroprusside reversibly attenuated the pressor responses to both adrenal stimulation and epinephrine.”