Possible Interaction: Epinephrine and Nitroglycerin

“Plasma epinephrine and aldosterone concentrations and plasma renin activity were also increased after nitroglycerin administration.”

“Methylene blue and epinephrine decreased the calcium-blocking effect and the influence of nitroglycerin on cyclic guanosine 3'-5'-monophosphate content, but failed to suppress the inhibitory effect of sodium nitroprusside.”

“ Nitroglycerin , isosorbide dinitrate, and their biotransformation product, inorganic nitrite, inhibited platelet aggregation with collagen, epinephrine , arachidonate, and ionophore, and blocked both primary and secondary aggregation in response to ADP.”

“In vitro, la nitroglycérine antagonise aisément la contraction de l'artère carotidienne du chien provoquée par la noradrénaline , ce qui n'est pas le cas pour l'artère fémorale.”

“In the untreated group, intravenous injection of 12.5 micrograms/kg and 100 micrograms/kg of NG caused a dose-related fall in MBP and a dose-related rise in the plasma norepinephrine and epinephrine concentrations.”

“The results suggest that vasodilators such as nitroglycerin and nitroprusside can block the pressor response and pulmonary pathology subsequent to CC or EP.”

“Contraction velocity analysis revealed that nitroprusside and nitroglycerin reduced the tonic contribution to total epinephrine contraction by 64 and 47% respectively; the phasic contribution was reduced by approximately 50% by either vasodilator.”

“For aortic strips maximally contracted with epinephrine , only 70% relaxation was achieved with single maximal effective doses of nitroprusside or nitroglycerin , and the ED 50 was increased 25- and 630-fold respectively.”

“Pretreatment of aortic strips with nitroprusside or nitroglycerin decreased their reactivity to epinephrine (decrease of potency and intrinsic activity) and completely blocked angiotensin contractions.”