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Possible Interaction: Epinephrine and Nifedipine

supplement:

Epinephrine

Research Papers that Mention the Interaction

Epinephrine-induced aggregation was inhibited by low concentrations of verapamil while nifedipine only inhibited aggregation by epinephrine at much higher concentrations.
Thrombosis and haemostasis  •  1983  |  View Paper
Local administration of nifedipine (200 μM) suppressed NE release by approximately 40% and Epi release by approximately 30%, but did not affect ACh release.
Autonomic Neuroscience  •  2013  |  View Paper
Nifedipine (an L-type Ca(2+) channel antagonist, 300 and 900 microg/…) did not change ACh release at 2 and 4 Hz; however, nifedipine (300 microg/…) inhibited epinephrine release at 4 Hz by 20%, and nifedipine (900 microg/kg) inhibited norepinephrine and epinephrine releases at 4 Hz by 30%.
American journal of physiology. Regulatory, integrative and comparative physiology  •  2004  |  View Paper
Infusion of two calcium-channel blocking …, verapamil (VP) and nifedipine ND ) at the site of arrhythmogenesis, in equimolar … of 3 x 10(-3) M alongwith EP in the same vehicle reduced the incidence, duration, peak and mean frequencies … arrhythmias while, the latent period of onset of arrhythmias increased significantly.
Indian journal of experimental biology  •  1998  |  View Paper
Nifedipine (0.3-3 microg/min) inhibited the ACh- and DMPP-induced increases in EPI and NE output without affecting the SNS- and muscarine-induced increases in EPI and NE output.
Journal of cardiovascular pharmacology  •  1998  |  View Paper
Studies on the possible involvement of secondary messengers in cell expansion indicated that (i) both 8-bromo-CAMP and forskolin caused cell shrinking (the …) phospholipid derivatives, such as 1,2-dioctanoyl-sn-glycerol, lysophosphatidic acid, and arachidonic acid caused cell expansion; and (iv) EGTA (calcium chelator) and nifedipine (… epinephrine.
Cell biology international  •  1993  |  View Paper
However, nifedipine significantly depressed the maximum response to epinephrine in tail arteries isolated from acute footshock-stressed rats.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas  •  1992  |  View Paper
Serum epinephrine and norepinephrine levels increased after the infusion of nifedipine and suggested that fentanyl did not completely overcome the sympathetic response to the profound vasodilatation.
Journal of cardiothoracic anesthesia  •  1989  |  View Paper
Nifedipine abolished the action of epinephrine but had no effect on norepinephrine.
Journal de biologie buccale  •  1987  |  View Paper
At a dose of 500 micrograms/kg, nifedipine inhibited thrombotic sudden death provoked by arachidonic acid, a thromboxane agonist (U46619), or a combination of collagen and epinephrine.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine  •  1986  |  View Paper
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