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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Epinephrine
drug:
Nifedipine
Research Papers that Mention the Interaction
“By contrast, nifedipine inhibited the increase in plasma adrenaline induced by exercise.”
Effect of nifedipine on plasma catecholamines in man at rest and during exercise“The effect of nifedipine was less markedly reduced, especially by combinations which included adrenaline.”
“Epinephrine-induced aggregation was inhibited by low concentrations of verapamil while nifedipine only inhibited aggregation by epinephrine at much higher concentrations.”
“In the presence of nifedipine, adrenaline induced in pelvis preparations (but not in the ureter) a tonic contraction (T-component) which was on average 61% of the control reaction (SD±26%; n=35).”
A tonic component in the motility of the upper urinary tract (renal pelvis-ureter)“Nifedipine (an L-type Ca(2+) channel antagonist, 300 and 900 microg/…) did not change ACh release at 2 and 4 Hz; however, nifedipine (300 microg/…) inhibited epinephrine release at 4 Hz by 20%, and nifedipine (900 microg/kg) inhibited norepinephrine and epinephrine releases at 4 Hz by 30%.”
“Infusion of two calcium-channel blocking …, verapamil (VP) and nifedipine ND ) at the site of arrhythmogenesis, in equimolar … of 3 x 10(-3) M alongwith EP in the same vehicle reduced the incidence, duration, peak and mean frequencies … arrhythmias while, the latent period of onset of arrhythmias increased significantly.”
“ Nifedipine (0.3-3 microg/min) inhibited the ACh- and DMPP-induced increases in EPI and NE output without affecting the SNS- and muscarine-induced increases in EPI and NE output.”
“Noradrenaline output decreased from 4.33 +/- 0.84 nmol/30 min to 0.16 +/- 0.49 nmol/30 min and adrenaline output decreased from 3.16 +/- 1.66 nmol/30 min to -0.01 +/- 0.24 nmol/30 min in the presence of nifedipine.”
“Studies on the possible involvement of secondary messengers in cell expansion indicated that (i) both 8‐bromo‐CAMP and forskolin caused cell shrinking (the …) phospholipid derivatives, such as 1,2‐dioctanoyl‐sn‐glycerol, lysophosphatidic acid, and arachidonic acid caused cell expansion; and (iv) EGTA (calcium chelator) and nifedipine (… epinephrine.”
“However, nifedipine significantly depressed the maximum response to epinephrine in tail arteries isolated from acute footshock-stressed rats.”
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