Possible Interaction: Epinephrine and Nicotine

“The interaction of nicotine with the HT-29 cells stimulated the epinephrine secretion causing an increase in epinephrine release concentration, and enabling the conclusion that epinephrine and nicotine play an important role in the colorectal tumour growth.”

“ Nicotine increased the secretion of IL-8 from HGECs that were cultured in the presence of IL-1β or P. gingivalis LPS and also induced the phosphorylation of extracellular signal-regulated kinase (ERK) in epi 4.”

“The pattern of haemodynamic changes in the forearm indicates that epinephrine may be the mediator of the circulatory effects of nicotine.”

“ Nicotine interacted with the response of adrenergic agonists both in arteries and veins; in arteries it potentiates the contractile response of epinephrine ; in veins, it inhibited the dilatory responses of norepinephrine and potentiated the contractile effect of high concentration of epinephrine (10(-6) M).”

“Additional findings include the fact that the pressor action of epinephrine is potentiated by moderate amounts of nicotine , possibly resulting from at least partial paralysis of the parasympathetic ganglia.”

“The results indicate that with small to moderate doses of nicotine , release of epinephrine from the adrenal medulla contributes substantially to the pressor response obtained.”

“…,nicotine, … epinephrine and norepinephrine release, and enhances vasoconstriction by impairing endothelium-dependent and endotheliumindependent vasodilation; it may therefore hinder tissue perfusion.9,10 In this randomized, … regular current snus users (one or more sachets daily in the last 30 days).11 Their ages ranged from 18 to 45 years.”

“ Epinephrine can restore a reflex discharge depressed or abolished by nicotine.”

“ RESULTS Nicotine , angiotensin II, and K+ each elicited time-related release of epinephrine , norepinephrine and dopamine by up to fourfold compared to the control.”

“Independent administration of nicotine , or the application of the physical restraint stressor, resulted in increases in the plasma concentrations of corticosterone, epinephrine , norepinephrine, and glucose.”

“ Nicotine administration during restraint stress enhanced the increase in plasma corticosterone and epinephrine , as compared to the responses induced by either factor alone.”

“In contrast, a single injection of nicotine elicited only a small increase in adrenal TH mRNA levels, which was transient and did not result in the induction of TH enzyme.”