“…,nicotine, … epinephrine and norepinephrine release, and enhances vasoconstriction by impairing endothelium-dependent and endotheliumindependent vasodilation; it may therefore hinder tissue perfusion.9,10 In this randomized, … regular current snus users (one or more sachets daily in the last 30 days).11 Their ages ranged from 18 to 45 years.”