Possible Interaction: Epinephrine and Nicergoline

“The effect of adrenaline and phenylephrine is blocked by nicergoline (10(-6) g/mL), increased obzidan (10(-6) g/mL) and does not change under the action ofyohimbine (10(-6) g/mL) and atenolol (10(-6) g/mL).”

“A possible role of adrenaline in platelet activationin vivo could justify the use of nicergoline (Sermion®), an alpha-adrenergic antagonist in combination therapy to prevent arterial thrombosis.”

“… nicergoline … adrenaline in the following situations: i) nicergoline inhibits the aggregation and secretion caused by adrenaline in cPRP (IC50 0.22 μM and 0.28 μM … administration of nicergoline (0.5 mg/kg per day) to patients inhibits significantly theex vivo response of their platelets to adrenaline in cPRP.”

“administration of nicergoline (0.06 approximately 4 mg/kg) caused a dose-dependent fall in BP and selective inhibition of pressure response to adrenaline (ID50: 0.25 mg/kg).”

“The washout of noradrenaline and adrenaline from the ischaemic myocardium following release of the occlusion was slightly enhanced by nicergoline.”

“In pithed rats treated with a β-adrenoceptor-blocking agent, nicergoline reduced the pressor responses to noradrenaline and adrenaline.”

“ Nicergoline slightly attenuated the pressor responses of dogs to noradrenaline and tyramine and, in addition, reversed the hypertension induced by adrenaline and dimethylphenyl-piperazinium.”

“ Nicergoline at 10 −7 M completely inhibited the adhesion of platelets to endothelial cells ‘activated’ by epinephrine.”