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Last Updated: 4 months ago

Possible Interaction: Epinephrine and Nicergoline

supplement:

Epinephrine

Research Papers that Mention the Interaction

The effect of adrenaline and phenylephrine is blocked by nicergoline (10(-6) g/mL), increased obzidan (10(-6) g/mL) and does not change under the action ofyohimbine (10(-6) g/mL) and atenolol (10(-6) g/mL).
Fiziologiia cheloveka  •  2014  |  View Paper
A possible role of adrenaline in platelet activationin vivo could justify the use of nicergoline (Sermion®), an alpha-adrenergic antagonist in combination therapy to prevent arterial thrombosis.
nicergoline … adrenaline in the following situations: i) nicergoline inhibits the aggregation and secretion caused by adrenaline in cPRP (IC50 0.22 μM and 0.28 μM … administration of nicergoline (0.5 mg/kg per day) to patients inhibits significantly theex vivo response of their platelets to adrenaline in cPRP.
Agents and Actions  •  2005  |  View Paper
administration of nicergoline (0.06 approximately 4 mg/kg) caused a dose-dependent fall in BP and selective inhibition of pressure response to adrenaline (ID50: 0.25 mg/kg).
Nihon yakurigaku zasshi. Folia pharmacologica Japonica  •  1986  |  View Paper
The washout of noradrenaline and adrenaline from the ischaemic myocardium following release of the occlusion was slightly enhanced by nicergoline.
Journal of cardiovascular pharmacology  •  1986  |  View Paper
In pithed rats treated with a β-adrenoceptor-blocking agent, nicergoline reduced the pressor responses to noradrenaline and adrenaline.
Nicergoline slightly attenuated the pressor responses of dogs to noradrenaline and tyramine and, in addition, reversed the hypertension induced by adrenaline and dimethylphenyl-piperazinium.
Journal of cardiovascular pharmacology  •  1981  |  View Paper
Nicergoline at 10 −7 M completely inhibited the adhesion of platelets to endothelial cells ‘activated’ by epinephrine.
Biochemical pharmacology  •  1980  |  View Paper