Possible Interaction: Epinephrine and Niacin

“ Nicotinic acid inhibited in vitro platelet aggregation induced by ADP, collagen and adrenaline.”

“Using a rat model of isolated perfused hindlimb, we tested whether this metabolite of nicotinamide is able to inhibit the vasoconstrictive effects of epinephrine , norepinephrine, and angiotensin II, thereby releasing prostacyclin from the endothelium.”

“These findings indicate an interaction of cholinergic receptors, both nicotinic and muscarinic, with hypothalamic epinephrine.”

“The lipolytic effect of adrenaline was modified by administering heparin or nicotinic acid.”

“The anti-lipolytic agent nicotinic acid had no effect on the initial mechanical responses of the heart to adrenaline but prolonged the period of enhanced tension development after adrenaline and reduced the degree of later deterioration in performance, in addition to blocking lipolytic stimulation.”

“An increase of adrenaline dose to 1000 mkg/kg was accompanied by reduction of the oxidized forms (by 22.2%) and of the total nicotinamide coferment level (by 18%).”

“Glucose, insulin, and nicotinic acid depressed and β -hydroxybutyrate increased fatty acid release rate stimulated by epinephrine.”

“Dimethyl pyrazole or nicotinic acid failed to elicit a rise in plasma GH during the intravenous infusion of epinephrine (0.5 μg/kg/min) despite a precipitous fall in FFA levels, confirmin...”

“Propranolol, imidazole, and nicotinic acid inhibited epinephrine stimulated activity.”

“ Nicotinic acid decreased cyclic AMP levels in the presence of epinephrine.”