Possible Interaction: Epinephrine and Nerve Growth Factor

“It may be concluded that NGF influences the liberation of adrenaline , noradrenaline and dopamine in tissue culture: though NGF treated cells contained more catecholamine granula, the catecholamines were retained in the pheochromocytoma cells.”

“The expression and release of inflammatory factors including NGF were enhanced by epinephrine.”

“The injection of NGF the TMJ sensitized by a previous TMJ injection of epinephrine also induced nociceptive behavior.”

“ Epinephrine and NGF showed synergism in their differentiating effects.”

“After 21 days, concentrations of norepinephrine and epinephrine were significantly increased in the group treated with nerve growth factor compared with those in the control group (211% norepinephrine and 322% epinephrine).”

“Both NGF and CNTF enhanced chromaffin cell survival and partially prevented losses of adrenaline during the 4‐day culture period in a dose‐dependent manner.”

“These results suggested that norepinephrine and epinephrine stimulated the de novo synthesis and secretion of NGF protein.”

“Treatment of the cells with either norepinephrine or epinephrine in the range of 0.05-0.2 mM for 24 h resulted in a 3-20-fold increase in NGF content in the medium of the L-M cells.”

“Both C6-CM and NGF increased the catecholamine content of the cultures and reduced the relative content of epinephrine.”

“Treatment with dexamethasone, but not NGF , also results in increased levels of epinephrine which parallel the increased PNMT in the ganglia.”