Possible Interaction: Epinephrine and Naloxone

“Furthermore, the combination of naloxone and epinephrine increased the NDS after cardiopulmonary resuscitation.”

“Moreover, the combination of naloxone and epinephrine may significantly increase resuscitation rate.”

“Further, low doses of Epi and naloxone , which were ineffective when administered alone, significantly enhanced retention when administered together.”

“The duration of the pressor response to epinephrine was significantly increased by naloxone , although no significant effects on survival were seen at 4 hours after the start of treatment.”

“These findings suggest that the buprenorphine may prove to be an alternative to naloxone, the co-administration of naloxone and epinephrine may be of benefit in the management of septic shock.”

“Treatment with naloxone or buprenorphine or naloxone + epinephrine resulted in significant improvement in MAP, pH and base excess.”

“Addition of NX after NBPH caused a further significant increase in EPI to levels greater than baseline (P < 0.002).”

“These results suggest that Epi released from the adrenal medulla of morphine-dependent rats mediates, in large part, the autonomic withdrawal responses elicited by naloxone.”

“The increase in EPI and NE output induced by 1 and 3 Hz of SNS was enhanced markedly by naloxone (10-1000 micrograms/kg i.v.)”

“Likewise, the duration of the pressor response to epinephrine was significantly increased by naloxone.”

“These findings suggest that the coadministration of naloxone and epinephrine may be of benefit in the treatment of shock.”

“… naloxone (5 … epinephrine (p less than 0.01) and norepinephrine (p less than 0.05) over shock levels along with a transient but significant increase in … 0.05) and mean arterial pressure (p less than 0.05), and a significant decrease in heart rate (p less than 0.05).”