Possible Interaction: Epinephrine and Naloxone

“In task 1, saline control animals showed good retention in a test session carried out 24 hr later; beta-endorphin, ACTH and epinephrine caused amnesia; beta-endorphin potentiated the amnesic effect of ACTH and epinephrine; and naloxone caused memory facilitation and reversed the amnesic effect of ACTH and epinephrine.”

“In task 2, control animals showed poor retention; beta-endorphin caused amnesia at the dose of ….1 but not 1.0 microgram/kg; the other three drugs caused memory facilitation; naloxone potentiated the facilitatory … of ACTH and epinephrine ; and beta-endorphin reversed it and … it into a deep amnesia.”

“ CONCLUSION Naloxone combined with epinephrine significantly increased the resuscitation rate in a rat model.”

“Furthermore, the combination of naloxone and epinephrine increased the NDS after cardiopulmonary resuscitation.”

“Moreover, the combination of naloxone and epinephrine may significantly increase resuscitation rate.”

“Further, low doses of Epi and naloxone , which were ineffective when administered alone, significantly enhanced retention when administered together.”

“In both tasks, naloxone facilitated retention and blocked the memory-impairing effects of Epi.”

“… naloxone to morphine-treated (tolerant) … content of norepinephrine, epinephrine and dopamine (290.2 (11.9) ng g-1, 15.6 (2.1) ng g-1 and 9.52 (0.…) and an increase (1.38 (0.2) ng g-1 in the dihydroxy phenyl acetic acid/dopamine (DOPAC/DA) ratio.”

“administration of naloxone attenuated the restraint stress-induced rise of plasma ACTH, E and NE levels.”

“Adding naloxone (1 mg/kg) to the treatment regimen enhanced the blockade of epinephrine excretion and largely prevented the antibody-induced increase in Met-EnK-IR.”

“The more common (-)isomer of naloxone increased the contractile response to epinephrine only at the higher dose tested (4 mg).”

“The duration of the pressor response to epinephrine was significantly increased by naloxone , although no significant effects on survival were seen at 4 hours after the start of treatment.”

“These findings suggest that the buprenorphine may prove to be an alternative to naloxone, the co-administration of naloxone and epinephrine may be of benefit in the management of septic shock.”

“Treatment with naloxone or buprenorphine or naloxone + epinephrine resulted in significant improvement in MAP, pH and base excess.”

“ Naloxone enhanced the contractile response to epinephrine without altering coronary artery or coronary sinus epinephrine concentrations or myocardial epinephrine uptake.”

“ Naloxone enhanced the inotropic effect (peak +dP/dt) during epinephrine infusion.”