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Possible Interaction: Epinephrine and Naloxone

supplement:

Epinephrine

Research Papers that Mention the Interaction

In task 1, saline control animals showed good retention in a test session carried out 24 hr later; beta-endorphin, ACTH and epinephrine caused amnesia; beta-endorphin potentiated the amnesic effect of ACTH and epinephrine; and naloxone caused memory facilitation and reversed the amnesic effect of ACTH and epinephrine.
In task 2, control animals showed poor retention; beta-endorphin caused amnesia at the dose of ….1 but not 1.0 microgram/kg; the other three drugs caused memory facilitation; naloxone potentiated the facilitatory … of ACTH and epinephrine ; and beta-endorphin reversed it and … it into a deep amnesia.
Psychoneuroendocrinology  •  1983  |  View Paper
CONCLUSION Naloxone combined with epinephrine significantly increased the resuscitation rate in a rat model.
Furthermore, the combination of naloxone and epinephrine increased the NDS after cardiopulmonary resuscitation.
The Journal of emergency medicine  •  2010  |  View Paper
Moreover, the combination of naloxone and epinephrine may significantly increase resuscitation rate.
The American journal of emergency medicine  •  2008  |  View Paper
Further, low doses of Epi and naloxone , which were ineffective when administered alone, significantly enhanced retention when administered together.
In both tasks, naloxone facilitated retention and blocked the memory-impairing effects of Epi.
Psychopharmacology  •  2004  |  View Paper
naloxone to morphine-treated (tolerant) … content of norepinephrine, epinephrine and dopamine (290.2 (11.9) ng g-1, 15.6 (2.1) ng g-1 and 9.52 (0.…) and an increase (1.38 (0.2) ng g-1 in the dihydroxy phenyl acetic acid/dopamine (DOPAC/DA) ratio.
British journal of anaesthesia  •  1998  |  View Paper
administration of naloxone attenuated the restraint stress-induced rise of plasma ACTH, E and NE levels.
Brain research  •  1997  |  View Paper
Adding naloxone (1 mg/kg) to the treatment regimen enhanced the blockade of epinephrine excretion and largely prevented the antibody-induced increase in Met-EnK-IR.
Journal of neurochemistry  •  1995  |  View Paper
The more common (-)isomer of naloxone increased the contractile response to epinephrine only at the higher dose tested (4 mg).
Circulatory shock  •  1993  |  View Paper
The duration of the pressor response to epinephrine was significantly increased by naloxone , although no significant effects on survival were seen at 4 hours after the start of treatment.
These findings suggest that the buprenorphine may prove to be an alternative to naloxone, the co-administration of naloxone and epinephrine may be of benefit in the management of septic shock.
Treatment with naloxone or buprenorphine or naloxone + epinephrine resulted in significant improvement in MAP, pH and base excess.
Ma zui xue za zhi = Anaesthesiologica Sinica  •  1993  |  View Paper
Naloxone enhanced the contractile response to epinephrine without altering coronary artery or coronary sinus epinephrine concentrations or myocardial epinephrine uptake.
Naloxone enhanced the inotropic effect (peak +dP/dt) during epinephrine infusion.
Circulatory shock  •  1990  |  View Paper
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