Possible Interaction: Epinephrine and Moxonidine

“Plasma norepinephrine, epinephrine , and plasma renin activity were significantly reduced by moxonidine , and blood pressure reduction corresponded with decrease of plasma norepinephrine.”

“ Moxonidine has been shown to diminish sympathetic activity, as measured by norepinephrine, epinephrine and plasma renin activity.”

“ Moxonidine results in a fall in adrenaline , noradrenaline and renin levels in humans, as might be expected from central inhibition of sympathetic tone.”

“ Moxonidine reduces adrenaline , noradrenaline and renin levels in man, a finding consistent with central inhibition of sympathetic tone.”

“ Moxonidine … adrenaline from 63.2 ± 6.6 to 49.0 ± 6.7 pg/ml (p < 0.005), the supine arterial plasma levels of noradrenaline from 187.…) and the orthostatic venous plasma levels of noradrenaline from 258.6 ± 25.0 to 190.3 ± 16.4 pg/ml (p = 0.03).”

“For all the group of imidazol(in)e drugs, excepting UK 14,304 and moxonidine , a significant inhibition of the epinephrine induced aggregation was noted.”

“ Moxonidine as an SIR modulator elicits a persistent reduction in circulating levels of epinephrine , demonstrating a reduction in sympathetic tone.”