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Discover Supplement-Drug Interactions
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Last Updated: 4 years ago
supplement:
Epinephrine
drug:
Metyrosine
Research Papers that Mention the Interaction
“The incubation with α-MPT inhibited ovarian l-DOPA, dopamine (DA), norepinephrine (NE) and epinephrine (EP) levels and the l-DOPA supplementation compensated the inhibitory effect.”
An in vitro study on catecholamine modulation of ovarian steroidogenic activity in the catfish Heteropneustes fossilis.“However, ketamine induced significant anesthesia even at a dose of 30mg/kg in animals in which production of endogenous catecholamine adrenalin , noradrenalin dopamine) was inhibited with metyrosine at a level of 45-47%.”
The suppression of endogenous adrenalin in the prolongation of ketamine anesthesia.“ Metyrosine reduces the epinephrine levels without affecting the corticosterone levels, thereby creating an analgesic effect.”
“We also found that adrenalin levels are reduced upon metyrosine treatment, which may be the cause of the observed gastro-protective effects of this compound.”
“The α-MPT treatment decreased significantly the content and turnover of dopamine (DA), noradrenaline (NA), and adrenaline (A) but did not influence the 5-HT content or turnover.”
Effects of melatonin, p-chlorophenylalanine, and α-methylparatyrosine on plasma gonadotropin level and ovarian activity in the catfish, Heteropneustes fossilis: A study correlating changes in hypothalamic monoamines
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