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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
supplement:
Epinephrine
drug:
Metyrapone
Research Papers that Mention the Interaction
“To simulate a state of altered glucocorticoid- and mineralocorticoid-receptor occupation, we administered metyrapone , an 11-beta-hydroxylase inhibitor, that blocks adrenal cortisol synthesis and inhibits the 11-beta-hydroxysteroiddehydrogenase type-1 enzyme in the central nervous system and investigated endocrine changes and the sleep electroencephalogram.”
Sleep endocrine effects of the 11-beta-hydroxysteroiddehydrogenase inhibitor metyrapone.“ Metyrapone pretreatment blocked the memory-enhancing effects of amphetamine, 4-OH amphetamine, and epinephrine but did not affect retention performance of otherwise untreated animals.”
“Posttraining injections of different doses of epinephrine (ranging from 0.0001 to 1.0 mg/kg) produced a dose-dependent memory enhancement for inhibitory avoidance training and metyrapone blocked the memory-enhancing effects of all these doses.”
Adrenocortical suppression blocks the memory-enhancing effects of amphetamine and epinephrine.“In vitro incubation of adrenal homogenate in the presence of metopirone caused a marked inhibition of corticosterone production, but there was only a 20% inhibition with 3-MC.”
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